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Calcium channel blockers and renal disease / [edited by] Nicolas Roberto Robles.

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Format:
Book
Contributor:
Robles, Nicolás Roberto.
Series:
Cerebrovascular Research and Disorders
Language:
English
Subjects (All):
Kidneys--Diseases--Chemotherapy.
Kidneys.
Calcium--Antagonists.
Calcium.
Physical Description:
1 online resource (195 p.)
Edition:
1st ed.
Place of Publication:
Hauppauge, NY : Nova Science Publishers, c2009.
Language Note:
English
Summary:
The use of calcium antagonists in hypertension & specifically, hypertensive & diabetic kidney disease provides the subject of this book. Scientific research has improved drug designs with better pharmacodynamic profile that allows once daily administration & twenty four hours antihypertensive effects.
Contents:
Intro
CALCIUM CHANNEL BLOCKERSAND RENAL DISEASE
CALCIUM CHANNEL BLOCKERS AND RENAL DISEASE
Contents
Preface
List of Authors
Pharmacology of CalciumAntagonists
Mechanisms of Action
Differences among Calcium-Antagonists
Clinical Pharmacology
Pharmacokinetics
Pharmacodynamics
Tolerance
Sympathetic Activation
Ankle edema
Other Untoward Effects
Therapeutic Uses
Hypertension
Angina Pectoris
Supraventricular Arrhythmias
Subarachnoid Hemorrhage
Myocardial Infarction
Risk of Cancer
Drug Interactions
Special Considerations
Older Patients
Metabolic Syndrome
Patients with Congestive Heart Failure
Overdose of CCBs
References
Calcium Antagonists and SystemicHypertension
Abstract
Calcium Channel Blockers:The Findings of Clinical Trials
Calcium Channel Blockers and Target OrganDisease
1. Calcium Channel Blockers and Arteriosclerosis
2. Use of Calcium Channel Antagonists in Coronary Disease(CHD)
3. Effects on Cerebrovascular Disease: Clinical Trials
4. Meta-Analysis on Cerebrovascular Outcomes
Conclusions
Effects of Calcium Antagonists inRenal Hemodynamics
1. Ca2+ Channels and Vasoconstriction
1.1. Diversity of Ca2+ Channels
1.2. The Traditional Vision: The Role of L-Type Ca2+ Channels
1.3. The Emerging Evidences for Other Types of Ca2+ Channels
2. The Use of CCBs for BP Control inHypertension
2.1. The Principle of Ca2+ Antagonism
2.2. The Mechanism of "Ca2+ Antagonism" in Hypertension
3. Effects of CCBs on Microcirculation andRenal Hemodynamics
3.1. CCBs and Renal Protection
3.2. Mechanisms for Beneficial Renal Effects of New CCBs
3.2.1. DHP-Insensitive Ca2+ Channels in the Microcirculation andKidneys
3.2.2. DHP-Insensitive Ca2+ Channels in the Sympathetic Nerves.
3.2.3. New DHPs Cause New Effects on Renal Function
3.2.4. Limitations and Pertaining Questions
Conclusion - Prospects
The Non-Hemodynamic Effects ofCalcium Channel Blockers on theKidney
1. Introduction
2. Antioxidant Effects
2.1. End-Stage Renal Disease
2.2. Diabetes
2.3. Effects of Associations
3. Effect on the Proliferation of MesangialCells
4. Effect on Fibrosis and Apoptosis
5. Other Effects
Summary
Renoprotective Effect of CalciumAntagonists in SystemicHypertension
Introduction
Overview of Relevant Trials Regarding CCBsand Renal Protection in HypertensivePatients
CCBs and Renal Protection in the Presenceof Preserved Renal Function
Blood Pressure Control andNephroprotection in Patients withEstablished Chronic Kidney Disease
Calcium Antagonists and RenalDisease
Effects Calcium Channel Blockers on RenalHemodynamics
Renoprotective Effect of CalciumAntagonists in Animals
Effects on the Progression of Renal Injuryin Humans
Calcium Antagonists versus Renin-Angiotensin Axis Blocking Drugs
Calcium Antagonists versus Diuretics
Comparison between Calcium-Antagonists
New Calcium Antagonists
Conclusion
Renal Ischaemia and CalciumChannel Blockers (CCBs)
Chronic Renal Ischaemia
Definition
Pathogenic Mechanisms
Epidemiology
Morphology
Clinical Presentation
Calcium Channel Blockers and RID
Contrast-Induced Nephropathy AND CCBs
Risk Factors OF CIN
Prevention of Radiocontrast Nephropathy
Calcium Antagonist after KidneyTransplantation
Drug Treatment in Post-TransplantationArterial Hypertension
Non Dihydropyridinic CalciumAntagonists and Renal Disease.
Nondihydropiridine Calcium ChannelBlockers vs Other Antihypertensive Agents
Combination Therapy
Index.
Notes:
Description based upon print version of record.
Includes bibliographical references and index.
ISBN:
1-61209-867-3
OCLC:
847090008

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