New quinolones with potential anti-MRSA activity / Saeed Emami.

Format:

Book

Author/Creator:

Emami, Saeed.

Series:

Cancer etiology, diagnosis, and treatments.

Cancer etiology, diagnosis and treatments series

Language:

English

Subjects (All):

Quinolone antibacterial agents.

Staphylococcus aureus infections--Chemotherapy.

Staphylococcus aureus infections.

Physical Description:

1 online resource (126 p.)

Edition:

1st ed.

Place of Publication:

New York : Nova Science Publishers, c2010.

Language Note:

English

Summary:

Quinolone antibacterial agents are among the most attractive drugs in the field of anti-infective chemotherapy. Quinolones target the essential bacterial type II topoisomerases, which are involved in DNA replication and metabolism. Despite a large number of quinolones approved for the treatment of bacterial infections, there have been progressive efforts for the discovery of new quinolones to overcome the problem of growing bacterial resistance. This book discusses the structural requirements of quinolones for anti-MRSA activity and introduce the newly developed quinolones to manage MRSA infections, their in-vitro effectiveness based on recent studies and structure-activity relationships.

Contents:

History of quinolones development

Mechanism of action

Mechanisms of quinolone resistance in S. aureus

General structural features (structure-activity relationships)

Newer quinolones with potential anti-MRSA activity.

Notes:

Description based upon print version of record.

Includes bibliographical references (p. [87]-104) and index.

Description based on print version record.

ISBN:

1-61470-368-X

OCLC:

776162520