Stem cells and regenerative medicine Volume 6, Molecular and cellular mechanisms / Philippe Taupin.

Format:

Book

Author/Creator:

Taupin, Philippe.

Series:

Cell biology research progress.

Cell biology research progress

Language:

English

Subjects (All):

Stem cells.

Regenerative medicine.

Physical Description:

1 online resource (154 p.)

Edition:

1st ed.

Other Title:

Molecular and cellular mechanisms

Place of Publication:

New York : Nova Science Publishers, c2011.

Language Note:

English

Summary:

Stem cells are the building blocks of the body. They can develop into any of the cells that make up our bodies. Stem cells carry a lot of hope for the treatment of a broad range of diseases and injuries, spanning from cancers, diabetes, genetic diseases, graft-versus-host disease, eye, heart and liver diseases, inflammatory and autoimmune disorders, to neurological diseases and injuries, particularly neurodegenerative diseases, like Alzheimer's and Parkinson's diseases, cerebral strokes, and traumatic brain and spinal cord injuries. Stem cell research is therefore as important for understanding the Physio- and pathology of the body as for development and therapy as well as for understanding the nervous system. This book provides an overview and in-depth analysis of recent developments in stem cell research and therapy.

Contents:

Intro

STEM CELLS AND REGENERATIVE MEDICINE. VOLUME 5. PATENTS AND CLINICAL TRIALS

Contents

Preface

Introduction: Therapeutic Neuronal Stem Cells: Patents at the Forefront*

Abstract

1. Background

2. Neural Stem Cells, Therapeutic Potential and Patents

3. Expert Opinion

Acknowledgments

References**

Chapter I Adult Neurogenesis and Pharmacology in Alzheimer's Disease and Depression

Introduction

Adult Neurogenesis in Alzheimer's Disease

Adult Neurogenesis in Depression

Discussion

Conclusion and Perspectives

References

Chapter II Adult Neurogenesis in the Pathogenesis of Alzheimer's Disease

Chapter III Therapeutic Potential of Adult Neural Stem Cells*

Neural Progenitor and Stem Cells

Neural Progenitor and Stem Cells in Vitro

Origin of Newly Generated Neuronal Cells in the Adult Brain

Therapeutic Potential of Adult NSCs

Cellular Therapy

Gene Therapy

Current and Future Developments

Chapter IV Human Neural Progenitor and Stem Cells*

1. Introduction

2. Chemistry

2.1 Proliferation Medium

2.2 Culture of Human Fetal Neural Progenitor and Stem Cells

3. Biology and Action

3.1 Growth Rate

3.2 Immunocytofluorescence

3.3 Differentiation of Human Fetal Neural Progenitor and Stem Cells

4. Expert Opinion

Chapter V Cryopreservation of Early Postmitotic Neuronal Cells in Culture*

2.1 Defined Derivation Medium

2.1.1 Defined Derivation Medium #1

2.1.2 Defined Medium #2

2.1.3 Defined Medium #3

2.2 Induction Medium

2.2.1 Induction Medium.

2.3 Production of Neural Progenitor Cells from Embryonic Stem Cells

2.4 Induction of Neural Progenitor Cells into Neuronal or Neural-Like Cells

2.5 Cryopreservation

2.6 Thawing Cryopreserved Cells

2.7 Cultivation

Chapter VI Adult Neural Stem Cells for the Treatment of Neuroinflammation*

3.1 Relapsing-Remitting Model of Experimental Autoimmune Encephalomyelitis

3.2 Syngeneic Transplantation

3.3 In Situ Proliferation of Transplanted Anscs

3.4 Immunocytology and Immunohistology

Chapter VII Adult Periodontal-Derived Neural Progenitor and Stem Cells*

2.1 Periodontal Tissue

2.2 Cell Culture

2.3 Differentiation

2.4 Immunocytology

2.5 Organotypic Hippocampal Slice Cultures

2.6 Further Studies

Chapter VIII Magnetic Resonance Imaging for Monitoring Neurogenesis in the Adult Hippocampus*

2.1 Experimental Study in Rats

2.2 MRI Scanning in Rats

2.3 Histology

2.4 Epidemiological Study

2.5 MRI Protocol in Human Subjects

Chapter IX Apigenin and Related Compounds Stimulate Adult Neurogenesis*

2.1 Compounds and Derivatives

2.2 Synthesis

3.1 Animal Studies

3.1.1 Intraperitoneal Administration of Apigenin

3.1.2 Oral Administration of Apigenin and Epicatechin

3.2 Immunohistology

3.3 Cell Culture

Acknowledgments.

References**

Chapter X Nootropic Agents Stimulate Neurogenesis*

2.1 Cell Culture

2.2 Differentiation

2.3 Immunocytochemistry

2.4 Novel Object Recognition Task

Chapter XI Fourteen Compounds and their Derivatives for the Treatment of Diseases and Injuries Characterized by Reduced Neurogenesis and Neurodegeneration*

3.1 Cell Culture

3.2 Immunocytology

3.3 Apoptosis

3.4 Necrosis

3.5 Neuron Dysfunction

Chapter XII Brevetoxin Derivative Compounds for Stimulating Neuronal Growth*

3.1 Primary Cell Culture of Neocortical Neurons

Chapter XIII OTI-010 Osiris Therapeutics/JCR Pharmaceuticals*

Summary

Synthesis and SAR

Preclinical Development

In Vitro

In Vivo

Toxicity

Clinical Development

GVHD

Transplantation in Cancer Patients

Crohn's Disease

Metabolism and Pharmacokinetics

Side Effects and Contraindications

Patent Summary

Current Opinion

Licensing

JCR Pharmaceuticals Co Ltd

Chapter XIV ADA-Transduced Hematopoietic Stem Cell Therapy for ADA-SCID

Phase I/II

References*

Index.

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

ISBN:

1-61761-388-6

OCLC:

923660004