Anticancer drugs : design, delivery and pharmacology / Peter Spencer and Walter Holt, editors.

Format:

Book

Contributor:

Holt, Walter.

Spencer, Peter, 1964-

Series:

Cancer etiology, diagnosis, and treatments.

Cancer etiology, diagnosis and treatments

Language:

English

Subjects (All):

Antineoplastic agents.

Antimitotic agents.

Cancer--Chemotherapy.

Cancer.

Drugs--Design.

Drugs.

Physical Description:

1 online resource (xi, 271 pages) : illustrations

Edition:

1st ed.

Place of Publication:

New York : Nova Biomedical Books, 2009.

Language Note:

English

Summary:

This book describes several ways to improve drug localisation and to increase anti-tumour efficacy, such as through drug modifications and through the development of anti-tumour drug delivery systems. Anticancer drugs have little or no specificity, resulting in low tumour concentrations, systemic toxicity and severe side effects. The pharmacological inhibitors of Hsp90, a major cytosolic chaperone, are examined in this book since they are often used in anticancer therapy. Furthermore, polyphenols, an anti-cancer agent which constitutes the most abundant group of antioxidants of normal human food, is discussed as well. Polyphenols protect against oxidative stress and their associated pathologies include inflammation, cancer and coronary heart diseases. Thus, they play an important role as an anticancer agent. Finally, metal-based antitumor drugs, which play an essential role in clinics today, are reviewed. In particular, ruthenium compounds as promising alternatives to platinum-based anticancer drugs.

Contents:

Micro- and nano-particulate drug delivery systems for cancer treatment / José L. Arias

Geldanamycin derivatives as promising anticancer drugs : therapy via Hsp90 inhibition / Alexander E. Kabakov

Synergistic antitumor activity of metronomic dosing chemotherapy in combination with liposomal anticancer drug / Tatsuhiro Ishida, Hiroshi Kiwada

Organotin polyethers as anticancer drugs / Charles E. Carraher, Michael R. Roner, Girish Barot

Studies on anti-cancer agents : phenolic compounds and their pharmacological activity / Maria Dolors Pujol, Isabel Sánchez

Design of novel anticancer drugs utilizing busulfan for optimizing pharmacological properties and pattern recognition techniques for elucidation of clinical efficacy / Ronald Bartzatt

Analysis of associations among novel property descriptors and their capacity in determining clinical efficacy by utilizing pattern recognition technigues / Ronald Bartzatt

Insights into the mode of action of bioreductive ruthenium cytotoxins / Erwin Reisner

Marina crystal minerals(MCM) induce apoptosis of human metastatic breast cancer MDA-MB-231 cells in vitro / Mamdooh Ghoneum, Takeshi Ogura, Sastry Gollapudi.

Notes:

Includes bibliographical references and index.

Description based upon print version of record.

ISBN:

1-60876-629-2

OCLC:

923658306