Endogenous Interferences in Clinical Laboratory Tests : Icteric, Lipemic and Turbid Samples / Martin H. Kroll, Christopher R. McCudden.

Format:

Book

Author/Creator:

Kroll, Martin H., Author.

McCudden, Christopher R., Author.

Series:

Patient Safety

Patient Safety ; 5

Language:

English

Subjects (All):

Clinical Chemistry Tests--methods.

Specimen Handling.

Bilirubin--isolation & purification.

Lipids--isolation & pruification.

Reproducibility of Results.

Patient Safety.

Medical Subjects:

Clinical Chemistry Tests--methods.

Specimen Handling.

Bilirubin--isolation & purification.

Lipids--isolation & pruification.

Reproducibility of Results.

Patient Safety.

Physical Description:

1 online resource (155 p.)

Edition:

1st ed.

Place of Publication:

Berlin ; Boston : De Gruyter, [2012]

Language Note:

English

Summary:

The goal of clinical laboratories is to produce accurate information for clinical decision making in medicine. More than half of the medical decisions made depend on clinical laboratory tests. Patient safety represents an important and critical problem for laboratories. They need to assure that the information they deliver to physicians is accurate, and therefore safe for clinicians to use. Endogenous compounds can interfere with laboratory tests, decreasing accuracy and threatening patient safety. Elevated bilirubin (bilirubinemia) and elevated lipids (lipemia) are common conditions that cause significant interferences with laboratory results. Clinicians depend on laboratories to detect these endogenous interferences. Laboratories must have a means to detect these endogenous interferences, make decisions about reporting results, and evaluate their impact. Most clinical pathology books provide only an abbreviated introduction to the subject, or provide a long list of references, without the necessary foundation for evaluating their significance. Package inserts typically provide scant information. This book provides the empirical and theoretical foundation for these interferences, describes the clinical settings where they occur, and explains their evaluation and detection, allowing the laboratory to interpret the available data on interferences and make the appropriate decision to effectively report test results while protecting patient safety.

Contents:

Frontmatter

Preface

Contents

1 Accuracy Goals for Laboratory Tests

2 Nature of Interferences

3 The Nature of Icteric Interference

4 The Nature of Lipemic and Turbidity Interferences

5 Measurement of Interference

6 Origin of Icteric Samples

7 Impact of Icterus

8 Origin of Lipemia and Turbidity

9 Impact of Lipemia/Turbidity

10 Endogenous Interferences in Clinical Laboratory Tests: Icteric, Lipemic and Turbid Samples

11 Reporting of Results

12 Analyte-dependent Interference

Index

Notes:

Description based upon print version of record.

Description based on online resource; title from PDF title page (publisher's Web site, viewed 21. Dez 2019)

ISBN:

9783110266221

3110266229

OCLC:

829462208