Molecular aspects of infectious disease / Mazen T. Saleh, editor.

Format:

Book

Contributor:

Saleh, Mazen T.

Series:

Immunology and Immune System Disorders

Immunology and immune system disorders

Nova biomedical

Language:

English

Subjects (All):

Molecular microbiology.

Communicable diseases--Molecular aspects.

Communicable diseases.

Pathology, Molecular.

Physical Description:

1 online resource (214 p.)

Edition:

1st ed.

Place of Publication:

New York : Nova Science Publishers, c2011.

Language Note:

English

Summary:

This book contains material relevant for students and researchers interested in the basic science of infectious diseases. The material in this book is organized into three major sections. The first describes the structures of various pathogenic microbes. The emphasis in this section is on the surface structures as they mediate the critical step of adsorption of pathogens to their target host cells. There is also a subsection on protein secretion in bacteria. The second section reviews the basics of innate immunity as these are the first line of immune defense and are important to understand the immunological response and its consequences on the health status and physiological balance in the host. The third section provides a description of a number of infectious diseases, particularly those of the respiratory system and prion-related infections.

Contents:

Intro

MOLECULAR ASPECTS OF INFECTIOUS DISEASE

Library of Congress Cataloging-in-Publication Data

Contents

Chapter I Overview

Epidemiology

Host-Pathogen Interaction

Emerging Infectious Diseases

Chapter II Structure and Function of Bacterial and Fungal Cell Walls

Bacterial Cell Walls

Gram-Positive Cell Walls

Mycobacterial Cell Walls

Gram-Negative Cell Walls

Fungal Cell Walls

Conclusion

References

Chapter III Bacterial Cell Surface Structures Important in Pathogenesis

Importance of the Bacterial Cell Surface

Bacterial Capsules and Slime Layers

S-Layers

Chapter IV An Introduction to Protein Secretion in Prokaryotes

Type I Secretion System (T1ss)

Architecture

Mechanism of Transport

Protein Folding

Summary

Type II Secretion System (T2ss)

General Secretory Pathway (Gsp)

Twin Arginine Translocation (Tat) Pathway

Outer Membrane Transport

Type III Secretion System (T3ss)

Type IV Secretion System (T4ss)

Type V Secretion System (T5ss)

Autotransporters (Va)

Two-Partner Secretion (Vb)

Oligomeric Coiled-Coil Adhesins (Vc)

Type VI Secretion System (T6ss)

Architecture and Mechanism of Transport

Type VII Secretion System (T7ss)

Chapter V Viruses

Basic Structure

The Viral Lifecycle within Host Cells

Survey of Medically Important Viruses

Therapeutic Strategies

Chapter VI The Innate Immune System

Abstract

1. General Description.

2. Nature of the Innate Immune System Repertoire

3. Mechanisms of Recognition by the Innate System - Receptor-Specific Responses

I. Secreted PRR

II. Cytoplasmic PRR

III. Cell Surface Receptors

Toll-Like Receptors

4. Cell Types and Processes Involved in the Innate Immune System

I. Innate Barriers to Infection

II. Innate Immune Cells

IV. Cytokine and Chemokine Production

5. Inflammatory Responses

6. Antigen Processing - Role of Innate Immunity in Stimulating Adaptive Immune Responses

7. Disorders of the Innate Immune System

Chapter VII Respiratory Infections

Introduction

Pulmonary Infections

Streptococcus Pneumoniae

Colonization of Upper Airways

Invasion and Dissemination

Immune Defense and Inflammation

Immune Evasion

PSEUDOMONAS AERUGINOSA

Clinical Significance

Pseudomonas Aeruginosa in CF

Mechanisms of Microbial Pathogenesis

Apoptosis of Host Cells Caused by Pseudomonas Aeruginosa

Molecular Mechanisms of Inflammation Caused by Pseudomonas Aeruginosa Infection

The Role of Airway Epithelial Cells in the Pathogenesis of Pseudomonas Aeruginosa Pulmonary Infections

Chapter VIII Prions

Infectious but Proteinaceous Pathogens

Isolation of Infectious Agents Composed of Proteins only

Identification of Prp Gene

Protein-only Hypothesis

Isoforms of Prion Protein: PrPc and PrPsc

PrPc Function in Physiology and Prion Pathogenesis

Structure of PrPc and PrPsc

Models of PrPsc Aggregates

Prion Replication

Acknowledgments

Chapter IX Transmissible Spongiform Encephalopathy (TSE)

Transmission of TSEs

Species Barrier

Prion Strain

Prion Pathogenesis.

TSEs in Humans and Animals

Clinical and Pathological Features

Human TSEs

Idiopathic TSEs: sCJD and Sporadic Fatal Insomnia

Inherited TSEs: fCJD, GSS and FFI

Acquired TSEs: kuru, iCJD, and vCJD

Animal TSes

Scrapie

BSE

CWD

Other Animal TSEs

Chapter X Diagnostic Microbiology

Direct Examination and Antigen Testing

Microscopic Examination

Common Stain Methods

Biochemical and Antigen Testing

Microorganism and Virus Culture

Primary Alive Culture

Culture using Living Cells

Immunological Diagnosis

Immunofluorescence Methods

Enzyme Immunoassays

Immunoblotting

Other Serologic Techniques

Molecular Diagnosis

Nucleic Acid Extraction

Non-Amplified Probe Methods

Amplification Methods

Signal Amplification

PCR-Target Amplification

Real Time PCR

Post Amplification Analyses

Colorimetric ELISA

Reverse Hybridization

Solid Nucleic Acid Arrays

Suspension Array Analysis

Sequencing

Index.

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

Description based on print version record.

ISBN:

1-61761-251-0

OCLC:

836871497