Regenerative medicine and cell therapy / edited by Jean-Francois Stoltz.

Format:

Book

Contributor:

Stoltz, J. F.

Series:

Biomedical and health research ; v. 77

Standardized Title:

Regenerative medicine and cell therapy (2012)

Language:

English

Subjects (All):

Regenerative medicine.

Stem cells--Transplantation.

Stem cells.

Physical Description:

1 online resource (464 p.)

Edition:

1st ed.

Place of Publication:

Amsterdam ; Washington, DC : IOS Press, 2012.

Language Note:

English

Summary:

Most human tissues do not regenerate spontaneously. Cell therapy and tissue engineering, which involve collecting cells from either the patient or a donor and introducing them into injured tissues or organs, sometimes after modifying their properties, offer promising solutions for regenerative medicine. Indeed, so promising are these therapies that current research has shifted from organ growth to cell therapy. The range of therapeutic applications is wide, including cardiac insufficiency, atherosclerosis, cartilage defects, bone repair, burns, diabetes and liver or bladder regeneration.This book, whilst not covering all aspects of regenerative medicine or cell therapy, offers a current overview of this emerging multidisciplinary field, which has been described as "the way to improve the health and quality of life by restoring, maintaining, or enhancing tissue and organ functions". It explores some of the problems and challenges encountered, such as the need to overcome risks of teratogenic effects and/or immune reactions, and deals with the legal issues involved in national regulations. The first 11 chapters of the book are devoted to basic knowledge of stem cells and the remaining 20 chapters deal with potential clinical applications: hematology, cardiac, vascular, osteoarticular, liver, skin, etc. - although of course it is impossible to envisage all of the applications which will undoubtedly be developed in the next decade or so.The book will be of interest to all researchers and clinicians involved in regenerative medicine or cell therapy.

Contents:

Title Page; Acknowledgments; Preface; Contents; Part I. Stem Cells; Therapeutical Potential of Stem Cells; Embryonic Stem Cells, a Promise of Therapeutic Applications; Mesenchymal Stem Cell Characterization; Mesenchymal Stem Cells; Mesenchymal Stem Cells in Regenerative Medicine; Umbilical Cord Mesenchymal Stem Cells: Biology and Clinical Application; Umbilical Cord Blood: From Current Use to Future Applications; Adipose Stem Cells: Identification, Properties and Interest for Clinical Applications; Circulating Stem Cells Including Endothelial Progenitor Cells

Cancer Stem Cells: The Example of Leukemic Stem CellsInfluence of Mechanical Forces on Cells and Tissues; Myofibroblasts: Origins and Regulation of Phenotype by Mechanical Signaling; Part II. Applications; Cell Therapy in Hematology: Hematopoietic Stem Cell Transplantations in 2012; Interaction Between Mesenchymal Stromal Cells and Acute Leukemia; Anti-Viral Immunotherapy After Allogeneic Hematopoietic Stem Cell Transplantation; Adipose Stromal/Stem Cell and Cardiovascular Repair; Bone Marrow-Derived Mesenchymal Stem Cells and Ischemic Cardiomyopathy; Heart Development and Cardiac Stem Cells

Cell Therapy for Muscular DystrophiesGene Therapy for the Treatment of Genetic Muscle Disease; Anti-Thrombogenic Strategies Toward Vascular Grafts Development; Neural Tissue Engineering Strategies; Chondrocytes and Mechanical Forces; Articular Cartilage Engineering; Chondrogenic Differentiation of Human Bone Marrow-Derived Mesenchymal Stem Cells; Mesenchymal Stem Cells in the Treatment of Cartilage Lesions; Subchondral Bone Alterations Associated with Marrow Stimulation for Articular Cartilage Repair - Experimental Data and Clinical Implications; Gene Therapy of Osteochondral Defects

Stem and Progenitor Cells for Liver Regenerative MedicineCell Therapy of Burns; Bioengineered Corneas: From Epithelial Cells Culture to 3D Models; Alternatives to Allogeneic Red Blood Cells Transfusion - In vitro Maturated Red Blood Cells a New Step in Cell Therapy; European Regulations of MSC for Clinical Uses; Author Index

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

ISBN:

1-299-33321-4

1-61499-076-X

OCLC:

828559661