Basophil granulocytes / Paul K. Vellis, editor.

Format:

Book

Contributor:

Vellis, Paul K.

Series:

Cell biology research progress.

Cell biology research progress series

Language:

English

Subjects (All):

Basophils.

Granulocytes.

Physical Description:

1 online resource (145 p.)

Edition:

1st ed.

Place of Publication:

New York : Nova Science Publishers, c2010.

Language Note:

English

Summary:

This work examines the latest research developments in the field of basophil granulocytes, sometimes referred to as basophils, which are the least common of the granulocytes, representing about 0.01% to 0.3% of circulating white blood cells.

Contents:

Intro

BASOPHIL GRANULOCYTES

CONTENTS

PREFACE

Chapter 1 NEGATIVE REGULATION OF FC RI-MEDIATED BASOPHIL ACTIVATION BY THE CBL FAMILY OF ADAPTOR PROTEINS

ABSTRACT

INTRODUCTION

The High Affinity Receptor for IgE: Structure and Function.

Mechanisms Underlying Negative Regulation of Basophil Activation.

CBL FAMILY PROTEINS

Domain Structure and Function of Cbl Proteins.

Fc RI Down-Regulation by Cbl-Mediated Ubiquitination.

Fc RI Down-Regulation by Cbl Adaptor Function.

Cbl-Mediated Down-Regulation of Non-Receptor PTKs Upon Fc RI Engagement.

Cbl-Mediated Regulation of PTKs in Unstimulated Basophils.

CONCLUSION

REFERENCES

Chapter 2 BASOPHILS, MAST CELLS AND LIVER CANCER

Liver Cancer: A Still Complex Disease

Mast Cells: A Heterogeneous Cell Population

Human Basophils Granulocytes: A Rare But Emerging Inflammatory Cell Population

Mast Cells, Basophil Granulocytes and the Liver Cancer

CONCLUSIONS

Chapter 3 BASOPHILIC GRANULOCYTE: A REVIEW OF ITS CHARACTERISTICS AND ROLES

Phenotype, Development, and Activation of Basophils

Basophils and Anaphylaxis

(1) Classical pathway of anaphylaxis by mast cells and IgE

(2) A new anaphylaxis pathway that involves basophils and IgG

(3) Platelet-activating factor and basophil-mediated anaphylaxis

(4) The role of basophils in human anaphylaxis

Roles of Basophils in Chronic Allergic Reactions

(1) Roles of IgE in the chronic allergic reaction

(2) The role of basophils in the IgE-dependent chronic allergic inflammatory response

(3) Basophils as potential therapeutic targets for chronic allergic inflammation

The Role of Basophils in the Control of T Cell Differentiation

(1) T cell development and IL-4.

(2) The roles of basophils in Th2 cell development

Roles of Basophils in Immunological Memory Responses

Chapter 4 FLAVONOIDS, NATURAL INHIBITORS OF BASOPHIL ACTIVATION

I. Flavonoids Inhibit IL-4, IL-13 and CD40 Ligand Expression by Basophils

II. Clinical Effects of Flavonoids Identified with in Vivo Animal Models

III. Flavonoids Ameliorated Ocular Symptoms of Japanese Cedar Pollinosis

ACKNOWLEDGMENTS

Chapter 5 BASOPHIL IN TROPICAL INFECTIONS

BASOPHIL IN MALARIA

BASOPHIL IN DENGUE

BASOPHIL IN TUBERCULOSIS

BASOPHIL IN LEPROSY

Chapter 6 RESEARCH ON BASOPHIL IN THAILAND

BASOPHIL IN ALLERGY

BASOPHIL IN CANCER

BASOPHIL IN INFECTION

BASOPHIL IN INTOXICATION

WHAT SHOULD THE NEXT TREND OF RESEARCH IN THAILAND BE?

Chapter 7 BASOPHIL GRANULOCYTES: SMALL IN NUMBERS, MIGHTY IN IMMUNE REGULATION*

Chapter 8 C-REACTIVE PROTEIN: FCR RECEPTOR-MEDIATED EFFECTS ON HUMAN PERIPHERAL BLOOD BASOPHILS IN VITRO*

MATERIALS AND METHODS

Basophils Isolation

Reagents

Cell Incubations and Assessment of Basophil Response

Basophil Desensitizsation and Restimulation in Vitro

STATISTICAL ANALYSIS

RESULTS AND DISCUSSION

Basophil Responses to Human Aggregated IgG, C-Reactive Protein, and Fcgriii Cross-Linking

2. Basophil Responses to Cholinergic Drugs

3. Basophil Responses to Aggregated IgG and Cholinergic Drugs

4. Basophil Responses to Human C-Reactive Protein and Cholinergic Drugs

5. Joint Effects of CRP with aIigG and Antibody to CD16

6. Normal Human Blood Basophil Responses to Repeated Activation in Vitro

ACKNOWLEDGMENT

INDEX

Blank Page.

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

Description based on print version record.

ISBN:

1-61324-725-7

OCLC:

923660618