The toxicology of methanol / edited by John J. Clary.

Format:

Book

Contributor:

Clary, John J., 1937-

Language:

English

Subjects (All):

Methanol--Toxicology.

Methanol.

Methanol--Environmental aspects.

Physical Description:

1 online resource (305 p.)

Edition:

1st ed.

Place of Publication:

Hoboken, N.J. : Wiley, c2012.

Language Note:

English

Summary:

The Toxicology of Methanol presents a single source of information and an understanding of the toxicity of methanol from animal data, potential environmental effects as well as human effects. The animal data, which goes to making up the majority of the data on the toxicity of methanol and the mechanism of action, is reviewed as it relates to the potential toxicity in humans.

Contents:

The Toxicology of Methanol; Contents; Preface; Contributors; 1 Methanol Production and Markets: Past, Present, and Future; 2 Methanol: Fate and Transport in the Environment; 2.1 Introduction; 2.1.1 Release Scenarios; 2.1.2 Fate in the Environment; 2.2 Partitioning of Methanol in the Environment; 2.2.1 Methanol Partitioning Among Environmental Media; 2.2.2 Air/Water Partitioning; 2.2.3 Soil/Water Partitioning; 2.2.4 Methanol Dissolution; 2.2.5 Commingling/Cosolvency Effects; 2.3 Fate and Transport of Methanol in the Environment; 2.3.1 Soil and/or Groundwater Release

2.3.1.1 Sources of Methanol in Soil and Groundwater2.3.1.2 Losses of Methanol from Soil and Groundwater; 2.3.1.3 Methanol/BTEX Commingled Plumes; 2.3.2 Surface Water Release; 2.3.2.1 Sources of Methanol in Surface Water; 2.3.2.2 Losses of Methanol in Surface Water; 2.4 Methanol Additives; 2.4.1 Luminosity; 2.4.2 Taste; 2.5 Conclusions; References; 3 Human Toxicity; 3.1 Introduction; 3.2 Exposure; 3.2.1 Dietary; 3.2.2 Environmental; 3.3 Metabolism in Humans; 3.3.1 Normal; 3.3.2 High Exposure; 3.3.3 Over Exposure; 3.3.3.1 Symptoms; 3.3.3.2 Blood and Urine Methanol; 3.3.3.3 Urinary Formic Acid

3.3.3.4 Breath-Methanol Levels3.4 History of Human Toxicity; 3.4.1 Occupational; 3.4.2 Ingestion; 3.4.3 Dermal; 3.5 Controlled Human Studies; 3.6 In Utero Exposure; 3.7 Repeat Inhalation Exposure; 3.8 Management of Methanol Poisoning; 3.9 Conclusions; References; 4 General Animal and Aquatic Toxicity; 4.1 Introduction; 4.2 Acute Toxicity; 4.2.1 Oral; 4.2.2 Dermal; 4.2.3 Inhalation; 4.2.4 Intraperitoneal; 4.2.5 Subcutaneous; 4.2.6 Intravenous; 4.2.7 Other Acute Studies; 4.3 Irritation; 4.3.1 Dermal; 4.3.2 Eye; 4.4 Sensitization; 4.5 Repeat Exposure-Inhalation; 4.5.1 Non-Human Primates

4.5.2 Rats4.5.3 Mice; 4.5.4 Dogs; 4.6 Repeat Exposure-Oral; 4.6.1 Rats; 4.6.2 Non-Human Primates; 4.6.3 Mice; 4.7 Repeat Exposure-Dermal; 4.7.1 Mice; 4.8 Aquatic Toxicity; 4.9 Conclusion; References; 5 Developmental and Reproductive Toxicology of Methanol; 5.1 Introduction; 5.2 Reproductive Toxicity; 5.3 Developmental Toxicity; 5.3.1 Rats; 5.3.2 Mice; 5.3.3 Non-Human Primates; 5.3.4 Summary of Developmental Toxicity Findings in Experimental Animals Exposed to Methanol by Inhalation; 5.3.5 Pathogenesis of Methanol-Induced Birth Defects; 5.3.5.1 Whole Animal Studies; 5.3.5.2 In Vitro Studies

5.3.6 Folate Deficiency-A Susceptibility Factor for Methanol Developmental Toxicity?5.3.7 Role of Methanol and Metabolites in the Developmental Toxicity of Methanol; 5.4 Conclusions; Disclaimer; References; 6 Exploring Differences Between PBPK Models of Methanol Disposition in Mice and Humans: Important Lessons Learned; 6.1 Background; 6.2 Are Humans More or Less Sensitive than Mice to the Toxic Effects of Methanol?; 6.3 Are the Two Models' Predictions of Human Blood Methanol Concentrations at Steady State Consistent with Each Other?

6.4 Are the Values of Key Human Metabolism Parameters Consistent with Those in the Published Scientific Literature?

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

Description based on print version record and CIP data provided by publisher; resource not viewed.

ISBN:

9781118353110

1118353110

9781283978064

1283978067

9781118353097

1118353099

9781118353103

1118353102

OCLC:

826854566