Autophagy of the nervous system : cellular self-digestion in neurons and neurological diseases / editors, Zhenyu Yue, Charleen T Chu.

Format:

Book

Contributor:

Yue, Zhenyu.

Chu, Charleen T.

Language:

English

Subjects (All):

Nervous system--Diseases.

Nervous system.

Neurons.

Physical Description:

1 online resource (441 p.)

Edition:

1st ed.

Place of Publication:

Singapore ; Hackensack, N.J. : World Scientific Pub., c2012.

Language Note:

English

Summary:

What is autophagy? Why would neurons digest parts of themselves through autophagy? How can autophagy save the lives of cells under some conditions, but act as an accomplice to cell death in others? By what mechanisms are autophagy-related processes dysregulated in neurological diseases, and are there therapeutic strategies to correct or compensate for their dysfunction? This book provides an expert view of major concepts in autophagy research with a focus on autophagy in neurons. Experimental evidence for evolutionarily conserved and specialized regulatory mechanisms for autophagy in the mamma

Contents:

CONTENTS; Contributors; Preface; Section 1 Neuronal Autophagy: Cellular Process and Regulation; Chapter 1 The Cellular Process of Autophagy and Control of Autophagy in Neurons Nicole C. McKnight, Noboru Mizushima and Zhenyu Yue; INTRODUCTION; AUTOPHAGY PATHWAYS; AUTOPHAGY CORE MACHINERY; ULK1/ULK2 Kinase Complex (Atg1); Atg9 Recycling Complex; PI3-Kinase Complexes (Vps34-Beclin 1); Atg18/WIPI PI(3)P-Binding Protein and Atg2; Ubiquitin-like Conjugation Systems; Atg12 conjugation reaction; Atg8/LC3 conjugation reaction; SOURCE OF THE AUTOPHAGOSOME MEMBRANE

AUTOPHAGY SIGNALING/REGULATION OF AUTOPHAGYTHE ROLE OF LC3-BINDING PROTEINS IN AUTOPHAGY; AUTOPHAGY IN NEURONS; Compartmentalized Autophagy in Neurons; Autophagy Signaling in Neurons; Autophagic Clearance of Protein Aggregates in Neurons; Regulation of Neuronal Autophagy by Endosomal and ESCRT Machinery; Neuroprotective versus Neurotoxic Role of Autophagy; AUTOPHAGY IN NEURODEGENERATIVE DISEASES; CONCLUSION; ACKNOWLEDGMENTS; REFERENCES; Chapter 2 Autophagosome Maturation, Endocytosis and Neurodegenerative Disease Ai Yamamoto and Anne Simonsen; INTRODUCTION; MACROAUTOPHAGY

A Brief IntroductionAutophagosome Maturation: A Convergence with Endocytosis; Endocytosis; The maturation of an autophagosome to an autolysosome: Fusion with endocytic compartments; Vps34 complexes; Fusion with the lysosome; AUTOPHAGOSOME MATURATION AND NEURODEGENERATION; CONCLUDING REMARKS; REFERENCES; Chapter 3 Cross-Talk Between the Ubiquitin-Proteasome System and Macroautophagy Serhiy Pankiv and Terje Johansen; INTRODUCTION; THE UBIQUITIN-PROTEASOME SYSTEM (UPS); AUTOPHAGY; UPS AND AUTOPHAGY: CROSS-TALK AT THE REGULATORY LEVEL; UPS AND AUTOPHAGY: CROSS-TALK AT THE SUBSTRATE LEVEL

CONCLUSIONSREFERENCES; Chapter 4 Chaperone-Mediated Autophagy (CMA) in Neurons Maria Xilouri, Hsiao-Yu Peng and Leonidas Stefanis; INTRODUCTION; MECHANISM OF CMA; CMA IN THE NERVOUS SYSTEM; CMA IN NEURODEGENERATION: THE CASE FOR PARKINSON'S DISEASE; CMA IN OTHER NEURODEGENERATIVE DISEASES; CONCLUSION; ACKNOWLEDGEMENTS AND FUNDING; REFERENCES; Chapter 5 Maintaining Autophagic Balance: A Role for Brakes Salvatore J. Cherra, III and Charleen T. Chu; INTRODUCTION; OVERVIEW OF AUTOPHAGY INDUCTION; NEGATIVE REGULATORS OF AUTOPHAGY INDUCTION; Proteins Regulating Autophagy Induction

Mammalian target of rapamycinJumpy (myotubularin related protein 14); Bcl-2 (B cell CLL/lymphoma-2); FLICE-inhibitory proteins; Post-Translational Modifications that Regulate Autophagy Induction; Proteolysis of autophagy proteins; Regulation of autophagy by acetylation; Regulation of autophagy induction by phosphorylation; Regulation of LC3 by phosphorylation; AUTOPHAGY DOWNREGULATING MECHANISMS IN RELATION TO CANONICAL AND NON-CANONICAL INDUCTION PATHWAYS; ROLES OF AUTOPHAGY INHIBITION DURING DISEASE IN THE NERVOUS SYSTEM; CONCLUSION; REFERENCES; Section 2 Autophagy and Neurological Diseases

Chapter 6 Autophagy and Its Cross-Talk with Cell Death in Neural Development Sabrina Di Bartolomeo and Francesco Cecconi

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

ISBN:

1-283-85069-9

981-4350-45-1

OCLC:

817542260