From inflammation to cancer : advances in diagnosis and therapy for gastrointestinal and hepatological diseases / editors: Chi Hin Cho, Jun Yu.

Format:

Book

Contributor:

Cho, C.-H. (Chi-Hin)

Yu, Jun.

Language:

English

Subjects (All):

Gastroenteritis--Diagnosis.

Gastroenteritis.

Hepatitis--Diagnosis.

Hepatitis.

Gastrointestinal system--Cancer.

Gastrointestinal system.

Liver--Cancer.

Liver.

Physical Description:

1 online resource (378 p.)

Edition:

1st ed.

Place of Publication:

Hackensack, NJ : World Scientific, c2012.

Language Note:

English

Summary:

Inflammation and cancer are two major disorders that cause huge concerns in our society. However, what one may not know is that both diseases are closely associated and, in particular, both occur in the gastrointestinal tract and liver. This book describes the mechanics of how inflammation can progress to cancer in these organs. The authors in this book comprehensively discuss the different biomarkers for early diagnosis, and current therapeutic treatments for these diseases. All of these would allow us to better understand the pathogenesis of both diseases. As such, this book provides compreh

Contents:

About the Editors; Foreword; List of Main Contributors; Contents; Section I Inflammation and Cancer; Chapter 1 General Introduction Chung Wah Wu and Jun Yu; Introduction; How inflammation and cancer are linked; Inflammation conditions that are linked to specific GI cancers; Bowel cancer; Barrett's esophagus and esophageal cancer; Viral infections and hepatocellular carcinomas; H. pylori infection and gastric cancer; Conclusion; References; Chapter 2 General Mechanisms of Inflammation Liwei Lu and Min Yang; Categories of inflammation; Inflammatory process; Initiation of inflammation

Influx of leukocytesEffector mechanisms; Termination of inflammation and tissue repair; Regulatory mechanisms of inflammation; Conclusion; References; Chapter 3 Genetic and Epigenetic Alterations in Inflammation-Related Cancers - General Mechanisms of Cancers Yasuyuki Okamoto and Yutaka Kondo; Introduction; Signaling pathways; NF- κB; STAT3; RAS; TNF- α; TAM; Genetic instability; Epigenetic alterations; DNA methylation; Histone modifications; Perspectives; References; Chapter 4 From Inflammation to Cancer: The Molecular Basis Hongchuan Jin; Inflammation and cancer: a brief overview of history

Current model of tumorigenesis: interplay between tumor stem cells and tumor-permissive microenvironmentTumor microenvironment; Non-tumor cells in tumor microenvironment; Cancer-associated fibroblast (CAFs); Immune cells; Bioactive factors in tumor microenvironment; Chemokines; Growth factors; MMPs and TIMPs (tissue inhibitors of metalloproteinases); Other cytokines; Intracellular signaling pathways; NF- κB (nuclear factor κlight chain polypeptide gene enhancer in B cells) pathway; STAT3 (signal transducer and activator of transcription 3) pathway; Conclusions; References

Section II Models of Chronic Inflammation-Induced Cancers and Their TreatmentsChapter 5 Advances in the Treatment of Helicobacter pylori Infection and Gastric Cancer Guy D. Eslick; Introduction; Treatment of Helicobacter pylori infection; Guidelines for the treatment of H. pylori; Alternative therapies for H. pylori infection; Treatment of gastric cancer; Future directions in gastric cancer treatment; Prevention of gastric cancer by treating H. pylori infection; Conclusions; Acknowledgments; Dedication; References

Chapter 6 Inflammatory Bowel Disease and Colorectal Cancer and Their Treatment Crispin Corte and Rupert WL LeongIntroduction; Epidemiology; Pathological characteristics; Risk of dysplasia; Colitis CRC surveillance guidelines; 1. Timing of commencement of surveillance; 2. Surveillance interval; 3. Techniques in surveillance for CRC; Dye-spray chromoendoscopy; Narrow band imaging; Fluorescence imaging; Confocal endomicroscopy; Management of dysplasia; 1. Endoscopic management of dysplasia; 1.1. Visualised lesions; 1.2. Flat lesions; 2. Chemoprophylaxis; 2.1. 5-Aminosalicylatic acid

2.2. Ursodeoxycholic acid

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

ISBN:

1-283-63593-3

981-4343-60-9

OCLC:

811816466