Isocyanide chemistry : applications in synthesis and material science / edited by Valentine G. Nenajdenko.

Format:

Book

Contributor:

Nenajdenko, Valentine G.

Language:

English

Subjects (All):

Isocyanides.

Physical Description:

1 online resource (625 p.)

Edition:

1st ed.

Place of Publication:

Weinheim : Wiley-VCH, c2012.

Language Note:

English

Summary:

The efficacy of isocyanide reactions in the synthesis of natural or naturallike products has resulted in a renaissance of isocyanide chemistry. Now isocyanides are widely used in different branches of organic, inorganic, coordination, combinatorial and medicinal chemistry.This invaluable reference is the only book to cover the topic in such depth, presenting all aspects of synthetic isonitrile chemistry. The highlyexperienced and internationally renowned editor has brought together an equally distinguished team of authors who cover multicomponentreactions, isonitriles in total

Contents:

Isocyanide Chemistry: Applications in Synthesis and Material Science; Contents; Preface; List of Contributors; 1: Chiral Nonracemic Isocyanides; 1.1 Introduction; 1.2: Simple Unfunctionalized Isocyanides; 1.3 Isocyanides Containing Carboxylic, Sulfonyl, or Phosphonyl Groups; 1.3.1 α-Isocyano Esters; 1.3.2 α-Isocyano Amides; 1.3.3 Other Isocyano Esters or Amides; 1.3.4 Chiral Sulfonylmethyl or Phosphonylmethyl Isocyanides; 1.4 Isocyanides Containing Amino or Alcoholic Functionalities; 1.4.1 Chiral Amino or Azido Isocyanides; 1.4.2 Chiral Hydroxy Isocyanides; 1.5 Natural Isocyanides

1.5.1 Isolation and Natural Sources1.5.2 Synthesis of Naturally Occurring Isocyanides; 1.6 Isocyanides Used in the Synthesis of Chiral Polyisocyanides; 1.6.1 Properties; 1.6.2 Synthesis; 1.6.3 Applications; References; 2: General Aspects of Isocyanide Reactivity; 2.1 Introduction; 2.2 Isocyanide-Cyanide Rearrangement; 2.3 Oxidation/Reduction of the Isocyano Group; 2.3.1 Oxidation of the Isocyano Group; 2.3.2 Reactions with Sulfur and Selenium; 2.3.3 Reduction of the Isocyano Group; 2.4 Reactions of Isocyanides with Electrophiles; 2.4.1 Reaction with Acids

2.4.2 Reactions with Halogens and Acyl Halides2.4.3 Reactions with Activated Alkenes and Alkynes; 2.4.4 Reactions with Carbonyl Compounds and Imines; 2.4.5 Reactions with Activated Heterocumulens; 2.5 Reactions of Isocyanides with Nucleophiles; 2.5.1 Reactions with Organometallic Compounds; 2.5.2 Reactions with Hydroxide, Alcohols, and Amines; 2.6 Conclusions; References; 3: α-Acidic Isocyanides in Multicomponent Chemistry; 3.1 Introduction; 3.2 Synthesis of α-Acidic Isocyanides; 3.3 Reactivity of α-Acidic Isocyanides; 3.4 MCRs Involving α-Acidic Isocyanides; 3.4.1 van Leusen Imidazole MCR

3.4.2 2,6,7-Trisubstituted Quinoxaline MCR3.4.3 4,5-Disubstituted Oxazole MCR; 3.4.4 Nitropyrrole MCR; 3.4.5 2,4,5-Trisubstituted Oxazole MCR; 3.4.5.1 2,4,5-Trisubstituted Oxazoles; 3.4.5.2 Variations on the 2,4,5-Trisubstituted Oxazole MCR; 3.4.5.3 Oxazole MCR and In-Situ Domino Processes; 3.4.6 2-Imidazoline MCR; 3.4.6.1 2-Imidazoline MCR in the Union of MCRs; 3.4.7 Dihydropyridone MCR; 3.5 Conclusions; References; 4: Synthetic Application of Isocyanoacetic Acid Derivatives; 4.1 Introduction; 4.2 Synthesis of α-Isocyanoacetate Derivatives; 4.3 Alkylation of Isocyanoacetic Acid Derivatives

4.4 α-Isocyanoacetates as Michael Donors4.5 Reaction of Isocyanoacetic Acids with Alkynes: Synthesis of Pyrroles; 4.6 Reaction of Isocyanoacetic Acid Derivatives with Carbonyl Compounds and Imines; 4.6.1 Aldol-Type Reaction of Isocyanoacetic Acids with Aldehydes: Synthesis of Oxazolines; 4.6.2 Transition Metal-Catalyzed Aldol-Type Reactions; 4.6.3 Reaction of Isocyanoacetic Acids with Imines: Imidazoline Formation; 4.7 Reaction with Acylating Agents; 4.8 Multicomponent Reactions of Isocyanoacetic Acid Derivatives; 4.9 Chemistry of Isocyanoacetates Bearing an Additional Functional Group

4.10 Reactions of Isocyanoacetic Acids with Sulfur Electrophiles

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

ISBN:

9786613854735

9781283542289

1283542285

9783527652532

3527652531

9783527652563

3527652566

9783527652556

3527652558

OCLC:

802291228