Principles of clinical pharmacology / [edited by] Arthur J. Atkinson, Jr. ... [et al.].

Format:

Book

Contributor:

Atkinson, Arthur J., Jr.

Language:

English

Subjects (All):

Clinical pharmacology.

Pharmacology.

Physical Description:

1 online resource (649 p.)

Edition:

3rd ed.

Other Title:

Clinical pharmacology

Place of Publication:

London : Elsevier Academic Press, c2012.

Language Note:

English

Summary:

Principles of Clinical Pharmacology is a successful survey covering the pharmacologic principles underlying the individualization of patient therapy and contemporary drug development. This essential reference continues to focus on the basics of clinical pharmacology for the development, evaluation, and clinical use of pharmaceutical products while also addressing the most recent advances in the field. Written by leading experts in academia, industry, clinical and regulatory settings, the third edition has been thoroughly updated to provide readers with an ideal reference cover

Contents:

Front Cover; Principles of Clinical Pharmacology; Copyright; Contents; Preface to the First Edition; Contributors; Chapter1 - Introduction to Clinical Pharmacology; BACKGROUND; PHARMACOKINETICS; REFERENCES; PARTI - PHARMACOKINETICS; Chapter2 - Clinical Pharmacokinetics; THE TARGET CONCENTRATION STRATEGY; CONCEPTS UNDERLYING CLINICAL PHARMACOKINETICS; MATHEMATICAL BASIS OF CLINICAL PHARMACOKINETICS; REFERENCES; STUDY PROBLEMS; Chapter3 - Compartmental Analysis of Drug Distribution; FIT-FOR-PURPOSE MODELING OF DRUG DISTRIBUTION; PHYSIOLOGICAL SIGNIFICANCE OF DRUG DISTRIBUTION VOLUMES

PHYSIOLOGICAL BASIS OF MULTICOMPARTMENTAL MODELS OF DRUG DISTRIBUTIONCLINICAL CONSEQUENCES OF DIFFERENT DRUG DISTRIBUTION PATTERNS; ESTIMATING MODEL PARAMETERS FROM EXPERIMENTAL DATA; REFERENCES; STUDY PROBLEMS; COMPUTER-BASED TUTORIALS; Chapter4 - Drug Absorption and Bioavailability; DRUG ABSORPTION; BIOAVAILABILITY; KINETICS OF DRUG ABSORPTION AFTER ORAL ADMINISTRATION; REFERENCES; STUDY PROBLEMS; COMPUTER-BASED TUTORIALS; Chapter5 - Effect of Renal Disease on Pharmacokinetics; DRUG DOSING IN PATIENTS WITH IMPAIRED RENAL FUNCTION; EFFECTS OF RENAL DISEASE ON RENAL DRUG EXCRETION MECHANISMS

EFFECTS OF IMPAIRED RENAL FUNCTION ON NON-RENAL METABOLISMEFFECTS OF RENAL DISEASE ON DRUG DISTRIBUTION; EFFECTS OF RENAL DISEASE ON DRUG ABSORPTION; REFERENCES; STUDY PROBLEM; Chapter6 - Pharmacokinetics in Patients Requiring Renal Replacement Therapy; KINETICS OF INTERMITTENT HEMODIALYSIS; KINETICS OF CONTINUOUS AND SUSTAINED RENAL REPLACEMENT THERAPY; CLINICAL CONSIDERATIONS; REFERENCES; COMPUTER-BASED TUTORIAL; Chapter7 - Effect of Liver Disease on Pharmacokinetics; HEPATIC ELIMINATION OF DRUGS; EFFECTS OF LIVER DISEASE ON PHARMACOKINETICS

USE OF THERAPEUTIC DRUGS IN PATIENTS WITH LIVER DISEASEREFERENCES; Chapter8 - Non-Compartmental and Compartmental Approaches to Pharmacokinetic Data Analysis; INTRODUCTION; KINETICS, PHARMACOKINETICS AND PHARMACOKINETIC PARAMETERS; NON-COMPARTMENTAL ANALYSIS; COMPARTMENTAL ANALYSIS; NON-COMPARTMENTAL VS COMPARTMENTAL MODELS; CONCLUSION; REFERENCES; Chapter9 - Distributed Models of Drug Kinetics; INTRODUCTION; CENTRAL ISSUES; DRUG MODALITY I: DELIVERY ACROSS A PLANAR-TISSUE INTERFACE; DRUG MODALITY II: DELIVERY FROM A POINT SOURCE, DIRECT INTERSTITIAL INFUSION; SUMMARY; REFERENCES

Chapter10 - Population PharmacokineticsINTRODUCTION; ANALYSIS OF PHARMACOKINETIC DATA; POPULATION PHARMACOKINETICS; MODEL APPLICATIONS; CONCLUSIONS; REFERENCES; PARTII - DRUG METABOLISM AND TRANSPORT; Chapter11 - Pathways of Drug Metabolism; INTRODUCTION; PHASE I BIOTRANSFORMATIONS; PHASE II BIOTRANSFORMATIONS (CONJUGATIONS); ADDITIONAL EFFECTS ON DRUG METABOLISM; REFERENCES; Chapter12 - Methods of Analysis of Drugs and Drug Metabolites; INTRODUCTION; CHOICE OF ANALYTICAL METHODOLOGY; PRINCIPLES OF ANALYSIS; EXAMPLES OF CURRENT ASSAY METHODS; ASSAY SELECTION; REFERENCES

Chapter13 - Clinical Pharmacogenetics

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

ISBN:

0-12-385472-5

OCLC:

818109382