Hepatobiliary transport in health and disease / edited by Dieter Häussinger, Verena Keitel and Ralf Kubitz.

Format:

Book

Author/Creator:

Häussinger, D. (Dieter), 1951-

Contributor:

Häussinger, D. (Dieter), 1951-

Keitel, Verena.

Kubitz, Ralf.

Language:

English

Subjects (All):

Liver--Metabolism--Disorders.

Liver.

Biliary tract--Metabolism--Disorders.

Biliary tract.

Physical Description:

1 online resource (312 p.)

Edition:

1st ed.

Place of Publication:

Berlin : De Gruyter, c2012.

Language Note:

English

Summary:

One major function of the liver is the uptake of endo- and xenobiotics from the bloodstream and their excretion into bile. The transport systems involved in hepatobiliary transport have been recently cloned and characterized at the molecular level and it is becoming clear that mutations and polymorphisms of individual transporter molecules underlie a variety of liver diseases. Furthermore, new research has shown that bile acids, whose function in digestion is long known, also behave as signal molecules in a variety of organs, including the intestinal and biliary epithelia, sinusoidal endothelial and immune cells. This book provides indepth surveys on the structure and function of transport molecules involved in hepatobiliary transport, on the role of different bile acids receptors in various organs and their function in health and disease, the mechanisms of bile salt-induced apoptosis and hepatocyte protection, and the role of transporter mutations as causes and modifiers of liver diseases. The book will be of interest not only for biochemists, structural chemists and biologists, but also for clinicians.

Contents:

Sodium-dependent bile salt uptake

Sodium-independent bile salt uptake into hepatocytes

Bile salt export across the canalicular membrane

Bile salt salvage systems.

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

ISBN:

9781283858007

1283858002

9783110279344

3110279347

9783110279351

3110279355

OCLC:

796384275