Drug repositioning : bringing new life to shelved assets and existing drugs / edited by Michael J. Barratt, Donald E. Frail.

Format:

Book

Contributor:

Barratt, Michael J.

Frail, Donald.

Language:

English

Subjects (All):

Pharmaceutical industry--Economic aspects.

Pharmaceutical industry.

Drugs--Economic aspects.

Drugs.

Physical Description:

1 online resource (499 p.)

Edition:

1st ed.

Place of Publication:

Hoboken : John Wiley & Sons, c2012.

Language Note:

English

Summary:

The how's and why's of successful drug repositioning Drug repositioning, also known as drug reprofiling or repurposing, has become an increasingly important part of the drug development process. This book examines the business, technical, scientific, and operational challenges and opportunities that drug repositioning offers. Readers will learn how to perform the latest experimental and computational methods that support drug repositioning, and detailed case studies throughout the book demonstrate how these methods fit within the context of a comprehensive drug repositioning s

Contents:

Drug repositioning : the business case and current strategies to repurpose shelved candidates and marketed drugs / John Arrowsmith and Richard Harrison

Opportunities and challenges associated with developing additional indications for clinical development candidates and marketed drugs / Donald Frail and Michael Barratt

Clinical and operational considerations in repositioning marketed drugs and drug candidates / Damian O'Connell, David Sequeira, and Maria Miller

Regulatory considerations and strategies for drug repositioning / Ken Phelps

Computational and bioinformatic strategies for drug repositioning / Richard Mazzarella and Craig Webb

Mining scientific and clinical databases to identify novel uses for existing drugs / Christos Andronis ... [et al.]

Predicting the polypharmacology of drugs : identifying new uses through chemoinformatics, structural informatics and molecular modeling based approaches / Li Xie ... [et al.]

Systematic phenotypic screening for novel synergistic combinations: a new paradigm for repositioning existing drugs / Margaret Lee

Phenotypic in vivo screening to identify new, unpredicted indications for existing drugs and drug candidates / Michael Saporito, Christopher Lipinski, and Andrew Reaume

Old drugs yield new discoveries : examples from the prodrug, chiral switch and site-selective deuteration strategies / Adam Morgan ... [et al.]

Repurposing drugs for tropical diseases : case studies and open-source screening initiatives / Curtis Chong

Drug repositioning efforts by non-profit foundations

Business development strategies in the repositioning industry / Aris Persidis and Elizabeth Stark

A case study in drug repositioning : Sosei / Akinori Mochizuki and Makiko Aoyama.

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

ISBN:

9786613673718

9781118274392

1118274393

9781118274408

1118274407

9781280696756

1280696753

9781118274378

1118274377

OCLC:

795120559