Purine and pyrimidine metabolism.

Format:

Book

Conference/Event

Conference Name:

Symposium on Purine and Pyrimidine Metabolism (1976 : London, England)

Series:

Ciba Foundation symposium ; new ser. 48.

Ciba Foundation symposium (new series) ; 48

Language:

English

Subjects (All):

Purines--Metabolism--Congresses.

Purines.

Pyrimidines--Metabolism--Congresses.

Pyrimidines.

Physical Description:

1 online resource (xi, 369 pages) : illustrations

Edition:

1st ed.

Place of Publication:

Amsterdam ; New York : Elsevier/Excerpta Medica/North-Holland, 1977.

Language Note:

English

Summary:

The Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and discuss results. The Novartis Foundation, originally known as the Ciba Foundation, is well known to scientists and clinicians around the world.

Contents:

Purine and Pyrimidine Metabolism; Contents; Chairman's opening remarks; Purine and pyrimidine metabolism : pathways, pitfalls and perturbations; Discussion; Microbial models and regulatory elements in the control of purine metabolism; Discussion; Molecular nature of enzyme regulation in purine biosynthesis; Discussion; Genetic heterogeneity at the locus for hypoxanthine-guanine phosphoribosyltransferase; Discussion; Factors in the pathogenesis of the brain damage and anaemia in the Lesch-Nyhan syndrome; Discussion

Hypoxanthine-guanine phosphoribosyl; transferase activity in individual erythrocytes: autoradiographic studies in heterozygot; Discussion; Purine biosynthesis in mutant mammalian cells; Discussion; Purine and pyrimidine nucleotides in some mutant human lymphoblasts; Discussion; Superactivity of phosphoribosylpyrophosphate synthetase, due to feedback resistance, causing purine overproduction and gout; Discussion; Dietary feedback regulation of purine and pyrimidine biosynthesis in man; Discussion; Implications of disorders of purine metabolism for the kidney and the urinary tract; Discussion

The role of de novo purine synthesis in lymphocyte transformation; Discussion; Purine metabolism and control of cell proliferation; Discussion; The effect of adenosine on lymphoid cell proliferation and antibody formation; Discussion; Characterization of human adenosine deaminase; Discussion; The purinergic nerve hypothesis; Discussion; Inherited metabolic disease: prospects for the future in both basic and clinical research; Discussion; General discussion; Purine as regulators; Extracellular effects of adenosine; Membrane transport; Pyrimidine metabolism and immune function

Allopurinol and purine transport; Model systems for the study of purine and pyrimidine metabolism and their limitations; Animal models; Assessment of treatment : the Lesch-Nyhan syndrome; Ribose 5-phosphate and the oxidative pentose shunt in the regulation of purine synthesis de novo; Index of contributors; Subject index

Notes:

"Symposium on Purine and Pyrimidine Metabolism held at the Ciba Foundation, London, 9-11th June, 1976"--Participants page.

Includes bibliographical references and indexes.

ISBN:

9786613694065

9780444152565

0444152563

9781280783678

1280783672

9780470720301

0470720301

9780470717981

047071798X

OCLC:

798207670