Applications of transition metal catalysis in drug discovery and development : an industrial perspective / edited by Matthew L. Crawley, Barry M. Trost.

Format:

Book

Contributor:

Crawley, Matthew L.

Trost, Barry M.

Language:

English

Subjects (All):

Drug development.

Transition metal catalysts.

Physical Description:

1 online resource (376 p.)

Edition:

1st ed.

Place of Publication:

Hoboken, N.J. : John Wiley & Sons, c2012.

Language Note:

English

Summary:

This book focuses on the drug discovery and development applications of transition metal catalyzed processes, which can efficiently create preclinical and clinical drug candidates as well as marketed drugs. The authors pay particular attention to the challenges of transitioning academically-developed reactions into scalable industrial processes. Additionally, the book lays the groundwork for how continued development of transition metal catalyzed processes can deliver new drug candidates. This work provides a unique perspective on the applications of transition metal catalysis in drug discovery

Contents:

Transition metal catalysis in the pharmaceutical industry / Carl A. Busacca ... [et al.]

Selected applications of transition metal-catalyzed carbon-carbon cross-coupling reactions in the pharmaceutical industry / Hong C. Shen

Selected applications of Pd and Cu-catalyzed carbon-heteroatom cross-coupling reactions in the pharmaceutical industry / Jingjun Yin

Asymmetric cross-coupling reactions / William A. Szabo and Vince Yeh

Metathesis / Oliver Thiel

Transition metal-catalyzed synthesis of five and six membered heterocycles / Cheol K. Chung and Matthew L. Crawley

Oxidative catalysis / Lamont Terrell

Industrial asymmetric hydrogenation / Hans-Ulrich Blaser.

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

ISBN:

9786613622211

9781280592386

1280592389

9781118309834

1118309839

9781118309872

1118309871

9781118309865

1118309863

OCLC:

793995928