Green techniques for organic synthesis and medicinal chemistry [electronic resource] / editors, Wei Zhang, Berkeley W. Cue.

Format:

Book

Contributor:

Cue, Berkeley W.

Zhang, Wei, 1961-

Language:

English

Subjects (All):

Green chemistry.

Pharmaceutical chemistry.

Physical Description:

1 online resource (770 p.)

Edition:

1st ed.

Place of Publication:

Chichester, West Sussex : John Wiley & Sons, 2012.

Language Note:

English

Summary:

Green chemistry is a new way of looking at organic synthesis and the design of drug molecules, offering important environmental and economic advantages over traditional synthetic processes. Pharmaceutical companies are increasingly turning to the principles of green chemistry in an effort to reduce waste, reduce costs and develop environmentally benign processes. Green Techniques for Organic Synthesis and Medicinal Chemistry presents an overview of the established and emerging techniques in green organic chemistry, highlighting their applications in medicinal chemistry. The book is di

Contents:

GREEN TECHNIQUES FOR ORGANIC SYNTHESIS AND MEDICINAL CHEMISTRY; Contents; List of Contributors; Foreword; Preface; PART I: INTRODUCTION; 1 Green Toxicology; 1.1 Introduction; 1.2 History and Scope of Toxicology; 1.2.1 The need for green toxicology; 1.3 Principles of Toxicology; 1.3.1 Characteristics of exposure; 1.3.2 Spectrum of toxic effects; 1.3.3 The dose-response relationship; 1.4 Disposition of Toxicants in Organisms; 1.4.1 Absorption; 1.4.2 Distribution; 1.4.3 Metabolism; 1.4.4 Excretion; 1.5 Non-Organ System Toxicity; 1.5.1 Carcinogenesis; 1.5.2 Reproductive and developmental toxicity

1.5.3 Immunotoxicology1.6 Mechanistic Toxicology; 1.7 Quantitative Structure-Activity Relationships; 1.8 Environmental Toxicology; 1.8.1 Persistence and bioaccumulation; 1.9 Risk Assessment; 1.9.1 Non-Cancer risk assessment; 1.9.2 Cancer risk assessment; 1.10 Conclusions; References; 2 Green Chemistry and the Pharmaceutical Industry; 2.1 Introduction; 2.2 Green Chemistry versus Sustainable Chemistry; 2.3 Trend: The Ongoing Use of Hazardous Chemistry; 2.4 Myth: To Do Green Chemistry One Must Sacrifice Performance and Cost; 2.5 Green Chemistry and the Future of the Pharmaceutical Industry

2.6 Green Chemistry in Pharmaceutical Process Development and Manufacturing2.7 Conclusions; References; 3 Environmental Science; Guiding Green Chemistry, Manufacturing, and Product Innovations; 3.1 Introduction; 3.2 Market Forces; 3.2.1 Chemicals in the natural and human environment; 3.2.2 Precautionary decision making; 3.2.3 Chemical control laws; 3.2.4 Green chemistry initiatives; 3.2.5 Drug registration Environmental Risk Assessment (ERA); 3.2.6 Extended Producer Responsibility (EPR); 3.2.7 Ecosystem valuation; 3.2.8 Company expectations; 3.2.9 Public expectations

3.2.10 Environmental labeling, standards, and classification3.3 Indicators (Attributes) of Environmental Performance; 3.4 Environmental Impact; 3.5 Strategic Approach to Greener Manufacturing Processes and Products; 3.6 Manufacturing Process Improvements; 3.6.1 Business and Professional Advantages from Manufacturing Process Improvements; 3.7 Product Improvements; 3.8 Environmental Decision Making; 3.8.1 E-factor; 3.8.2 Process Mass Intensity (PMI); 3.8.3 Life Cycle Assessment (LCA); 3.8.4 Individual company initiatives; 3.8.5 Environmental (Ecological) Risk Assessment (ERA)

3.8.6 Alternatives Assessment (AA)/Chemical Alternatives Assessment (CAA)3.8.7 Green Screen; 3.8.8 iSUSTAINTM green chemistry index; 3.8.9 Computational science and Quantitative Structure-Activity Relationships (QSARs); 3.8.10 Tiered testing; 3.8.11 Databases and lists of chemicals; 3.9 Case Study - Pharmaceuticals/Biologics; 3.9.1 Pharmaceutical manufacturing; 3.9.2 Pharmaceutical products; 3.10 Case Study - Nanotechnology; 3.11 Green Credentials and Environmental Standards; 3.12 Inspiring Innovation - Academic and Industry Programs; 3.12.1 Academic programs; 3.12.2 Industry programs

3.13 Conclusions and Recommendations

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

Description based on print version record and CIP data provided by publisher.

ISBN:

1-283-85877-0

1-118-30865-4

0-470-71182-5

0-470-71181-7

OCLC:

797919706