Replacing animal models : a practical guide to creating and using culture-based biomimetic alternatives / edited by Jamie Davies.

Format:

Book

Contributor:

Davies, Jamie A.

Language:

English

Subjects (All):

Alternative toxicity testing.

Biomimetics--Methodology.

Biomimetics.

Physical Description:

1 online resource (223 p.)

Edition:

1st ed.

Place of Publication:

Chichester, West Sussex : John Wiley & Sons, 2012.

Language Note:

English

Summary:

Over the last decade, in vitro models have become more sophisticated and are at a stage where they can provide an effective alternative to in vivo experiments. Replacing Animal Models provides scientists and technicians with a practical, integrated guide to developing culture-based alternatives to in vivo experiments. The book is neither political nor polemical: it is technical, illustrating by example how alternatives can be developed and used and providing useful advice on developing others. After looking at the reasons for and potential benefits of alternatives to animal experiment

Contents:

Replacing Animal Models; Contents; Contributors; Preface; Section 1 Introductory Material; 1 Potential Advantages of Using Biomimetic Alternatives; 2 Overview of Biomimetic Alternatives; Section 2 Culture Methods; 3 Pancreatic Islets; 4 Endometrial Organoid Culture; 5 Modelling Lymphatic and Blood Capillary Patterning; 6 Precision-cut Lung Slices (PCLS); 7 Human Colon Tissue in Organ Culture; 8 Fetal Organ Culture; 9 Design of a Mechanical Loading Device to Culture Intact Bovine Spinal Motion Segments under Multiaxial Motion; 10 Magnetic Assembly of Tissue Surrogates

11 Assembly of Renal Tissues by Cellular Self-organizationSection 3 Case Studies of Use; 12 Hierarchical Screening of Pathways: Using Cell and Organ Cultures to Reduce use of Transgenic Mice; 13 Lung Organoid Culture to Study Responses to Viruses; 14 Organ-cultured Human Skin for the Study of Epithelial Cell Invasion of Stroma; 15 Organotypic Mandibular Cultures for the Study of Inflammatory Bone Pathology; 16 Three-dimensional, High-density and Tissue Engineered Culture Models of Articular Cartilage; 17 Concluding Remarks

Appendix 1 Sources of funding for development of culture-based alternativesAppendix 2 Databases and web-based discussions relevant to development of alternatives; Index; Color Plate

Notes:

Description based on print version record and CIP data provided by publisher.

Includes index.

ISBN:

9786613629081

9781119940982

1119940982

9781280599255

1280599251

9781118387733

1118387732

9781119940685

1119940680

9781119940678

1119940672

OCLC:

780063970