Steroid dimers : chemistry and applications in drug design and delivery / Lutfun Nahar, Satyajit D. Sarker.

Format:

Book

Author/Creator:

Nahar, Lutfun, Ph. D.

Contributor:

Sarker, Satyajit D.

Language:

English

Subjects (All):

Steroids.

Dimers.

Physical Description:

1 online resource (442 p.)

Edition:

1st ed.

Place of Publication:

Wiley 2012

Summary:

Steroid dimers are an important group of compounds produced by various marine organisms, and also synthesized in the laboratories. This group of compounds possesses various pharmacological and biological properties, and can also be used to create "molecular umbrellas" for drug delivery. Steroid Dimers: Chemistry and Applications in Drug Design and Delivery provides an up-to-date overview on the chemistry and applications of steroid dimers of natural and synthetic origins. The book includes easy-to-follow synthetic protocols for various classes of important dimeric steroids, so

Contents:

Steroid Dimers: Chemistry and Applications in Drug Design and Delivery; Contents; Preface; List of Abbreviations; 1 Introduction; 1.1 Steroids and Steroid Dimers; 1.2 General Physical and Spectroscopic Properties of Steroid Dimers; 1.3 Chromatographic Behaviour of Steroid Dimers; 1.4 Applications of Steroid Dimers; References; 2 Synthesis of Acyclic Steroid Dimers; 2.1 Dimers via Ring A-Ring A Connection; 2.1.1 Direct Connection; 2.1.2 Through Spacer Groups; 2.2 Dimers via Ring B-Ring B Connection; 2.2.1 Direct Connection; 2.2.2 Through Spacer Groups; 2.3 Dimers via Ring C-Ring C Connection

2.3.1 Through Spacer Groups2.4 Dimers via Ring D-Ring D Connection; 2.4.1 Direct Connection; 2.4.2 Through Spacer Groups; 2.4.3 Through Side Chain and Spacer Groups; 2.5 Dimers via Ring A-Ring D Connection; 2.5.1 Direct Connection; 2.6 Dimers via Connection of C-19; 2.7 Molecular Umbrellas; 2.8 Miscellaneous; References; 3 Synthesis of Cyclic Steroid Dimers; 3.1 With Spacer Groups: Cholaphanes; 3.2 Without Spacer Groups: Cyclocholates; References; 4 Naturally Occurring Steroid Dimers; 4.1 Cephalostatins; 4.2 Crellastatins; 4.3 Ritterazines; 4.4 Others; References

5 Synthesis of Cephalostatin and Ritterazine Analogues5.1 Introduction; 5.2 Synthesis of Cephalostatin and Ritterazine Analogues; 5.3 Total Synthesis of Naturally Occurring Cephalostatin 1; References; 6 Applications of Steroid Dimers; 6.1 Application of Steroid Dimers as 'Molecular Umbrellas': Drug Delivery; 6.2 Biological and Pharmacological Functions of Steroid Dimers: Drug Discovery and Design; 6.2.1 Antimalarial Activity; 6.2.2 Cytotoxicity and Anticancer Potential; 6.2.3 Effect on Micellar Concentrations of Bile Salts and Serum Cholesterol Level; 6.2.4 Effect on Bilayer Lipid Membranes

6.2.5 Supramolecular Transmembrane Ion Channels, and Artificial Receptors and Ionophores6.2.6 Other Properties; References; Index

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

ISBN:

1-280-58829-2

9786613618122

1-119-97094-6

1-119-97093-8

OCLC:

769141633