Muscle aging : inclusion-body myositis and myopathies / edited by Valerie Askanas and w. King Engel.

Format:

Book

Contributor:

Askanas, Valerie.

Engel, W. King.

Language:

English

Subjects (All):

Inclusion body myositis.

Physical Description:

1 online resource (272 p.)

Edition:

1st ed.

Place of Publication:

Oxford : Wiley-Blackwell, 2012.

Language Note:

English

Summary:

The aging of society is leading to many challenges across all areas of medicine. The problems of muscle aging have led to a rise in the incidence of less common conditions, which though not terminal are debilitating and frequently progressive, and often underdiagnosed or misdiagnosed. Written by a team of international experts, this landmark book will look at the general clinical problems associated with muscle aging before examining inclusion-body myositis and myopathies, a group of the more important diseases of muscle aging. With case vignettes to aid diagnosis to ensure correct management

Contents:

Ageing of the human neuromuscular system : pathological aspects / W. King Engel and Valerie Askanas

Aging of the human neuromuscular system : clinical considerations / W. King Engel and Valerie Askanas

Aging of the human neuromuscular system : patient vignettes / W. King Engel, Shalini Mahajan, Valerie Askanas

Mitochondrial changes in ageing with particular reference to muscle, and possible clinical consequences / Salvatore DiMauro, Eric Schon, Michio Hirano

Protein degradation in ageing cells and mitochondria : relevance to the neuromuscular system / Jenny Ngo and Kelvin Davies

Human muscle protein metabolism in relation to exercise and aging : potential therapeutic applications / Micah J. Drummond, Blake B. Rasmussen

Pathogenesis of sporadic inclusion-body myositis / Valerie Askanas, W. King Engel, Anna Nogalska

Inflammatory and autoimmune features of inclusion-body myositis / Marinos Dalakas

Clinical symptoms, physical findings, and diagnostic investigations / Frank Mastaglia

Pathologic diagnostic criteria of s-IBM and h-IBMS muscle biopsies / Valerie Askanas and W. King Engel

Function and mutations of the GNE gene leading to DMRV/h-IBM, animal models, and potential treatments / May Malicdan, Satoru Noguchi, Ichizo Nishino

Clinical and ethnic spectrum, laboratory data, and epidemiology of h-IBM due to GNE mutations / Zohar Argov, Ishizo Nishino, Ikiyo Nonaka

Consequences of the h-IBM characteristic GNE mutations on muscle proteins in vivo and in vitro / Aldobrando Broccolini and Massimiliano Mirabella

Function and structure of VCP mutations leading to h-IBM / Cezary Wojcik

Clinical spectrum, including myopathy, Paget's disease, and fronto-temporal dementia : experimental models of VCP mutations, and potential treatments / Virginia Kimonis

Animal models of h-IBM due to VCP mutation / Nisha M. Badders and Paul Taylor.

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

ISBN:

9786613408754

9781444398298

1444398296

9781444398311

1444398318

9781283408752

1283408759

9781444398281

1444398288

OCLC:

773301453