Heme biology : the secret life of heme in regulating diverse biological processes / editor, Li Zhang.

Format:

Book

Contributor:

Zhang, Li.

Language:

English

Subjects (All):

Heme.

Physical Description:

1 online resource (226 p.)

Edition:

1st ed.

Place of Publication:

Hackensack, N.J. : World Scientific, c2011.

Language Note:

English

Summary:

This invaluable book provides the first description of the diverse and fascinating functions of heme in life processes for a broad audience. It begins with an introduction to the intricate chemical properties of heme and the history of early observations of human diseases associated with heme. It then proceeds to describe the versatile roles of heme in controlling diverse molecular and cellular processes germane to human life and disease processes. Finally, an up-to-date review of human diseases associated with heme synthesis and application of heme synthesis in photodynamic therapy in cancer

Contents:

Preface; CONTENTS; List of Contributors; Chapter 1 Introduction Li Zhang; Overview; References; Chapter 2 Heme Biosynthesis and Degradation: What Happens when it goes Haywire? Li Zhang and Rebekah Sessoms; Overview; Heme is synthesized by the actions of eight enzymes in humans; Heme biosynthesis is regulated according to the needs for heme in human cells; Defective heme biosynthesis causes serious diseases in humans; Heme is degraded continuously in the human body; Defects in heme degradation can cause serious diseases; References

Chapter 3 Heme: An Ingenious Regulator of Gene Transcription Li ZhangOverview; Heme can control the activity of diverse transcriptional regulators; Heme serves as a secondary messenger of oxygen in yeast; Heme can control the expression of a high number of genes in yeast; The heme activator protein Hap1 is a key regulator of gene transcription in response to fluctuations in oxygen and heme levels; Heme regulation of Hap1 transcription-activating activity requires the proper functioning of Hsp90 and Hsp70 molecular chaperones

Bach1: A heme-dependent transcriptional regulator in mammalian cellsBach1, like Hap1, binds to heme via HRMs; Heme affects Bach1 at three levels; Perspectives; References; Chapter 4 Heme-Regulated eIF2α Kinase in Translation and Erythropoiesis Jane-Jane Chen and Rajasekhar NVS Suragani; Overview; Introduction; HRI is responsible for heme-regulated translation in erythroid precursors; Phosphorylation of eIF2α under diverse cellular stresses by the family of eIF2α kinases; Activation of HRI by autophosphorylation; Inhibition of HRI activity by heme

Two distinct heme-binding domains in the cooperation of heme-regulation of HRITissue expression and phylogenetic conservation of HRI; Coordination of heme and globin synthesis by HRI; Regulation of erythroid differentiation by HRI; Integrated stress response of eIF2αP signaling; Concluding remarks; Acknowledgement; References; Chapter 5 Role of Heme in Brain Functions: Dr. Jekyll or Mr. Hyde? Tatyana Chernova and Andrew G. Smith; Overview; Heme synthesis and disturbances pertinent to neuronal cells; Contradictory roles of heme as a toxic and a physiological molecule

Neurotoxic effects of hemeAcute damage; Chronic damage; Neuroglobin, hemoglobin and their neuroprotective roles; Heme oxygenases and neurodegenerative diseases: Where does heme come from?; Emerging regulatory roles for heme in neurons; Neurotrophic effects of heme; Heme can act as a gas-sensing regulator of brain functions; Heme and brain aging: Role of heme for protection from drug-induced neurotoxicity; May sufficient availability of heme delay aging?; Deficiency of heme and Alzheimer's disease; Heme in circadian pathways; References; Chapter 6 Heme and microRNA Biogenesis Feng Guo

Overview

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

ISBN:

9786613433312

9781283433310

1283433311

9789814287937

9814287938

OCLC:

858228382