Neurodegeneration : the molecular pathology of dementia and movement disorders / edited by Dennis W. Dickson and Roy O. Weller.

Format:

Book

Contributor:

Dickson, Dennis.

Language:

English

Subjects (All):

Nervous system--Degeneration.

Nervous system.

Dementia--Pathogenesis.

Dementia.

Movement disorders.

Physical Description:

1 online resource (497 p.)

Edition:

2nd ed.

Place of Publication:

Chichester, West Sussex ; Hoboken, NJ : Wiley-Blackwell, 2011.

Language Note:

English

Summary:

Most textbooks on neurodegenerative disorders have used a classification scheme based upon either clinical syndromes or anatomical distribution of the pathology. In contrast, this book looks to the future and uses a classification based upon molecular mechanisms, rather than clinical or anatomical boundaries. Major advances in molecular genetics and the application of biochemical and immunocytochemical techniques to neurodegenerative disorders have generated this new approach. Throughout most of the current volume, diseases are clustered according to the proteins that accumulate within cells

Contents:

Neurodegeneration: The Molecular Pathology of Dementia and Movement Disorders; Contents; List of Contributors; Preface; List of Abbreviations; Part 1: Introduction: Basic Mechanisms of Neurodegeneration; 1: Introduction to Neurodegeneration: The Molecular Pathology of Dementia and Movement Disorders; 2: Cell Death and Neurodegeneration; 3: Oxidative Stress and Balance in Neurodegenerative Diseases; 4: Protein Aggregation in Neurodegeneration; 5: Protein Degradation in Neurodegeneration: The Ubiquitin Pathway; 6: Genetics of Neurodegeneration; 7: Transgenic Animal Models of Proteinopathies

Part 2: Alzheimer's Disease and Aging8: Clinical Aspects of Alzheimer's Disease; 9: Genetics of Alzheimer's Disease; 10: Neuropathology of Alzheimer's Disease and its Variants; 11: Amyloid-ß Production; 12: Elimination of Amyloid ß from the Brain, its Failure in Alzheimer's Disease and Implications for Therapy; Part 3: Tauopathies; 13: Introduction to the Tauopathies; 14: Frontotemporal Dementia and Parkinsonism Linked to Chromosome 17; 15: Progressive Supranuclear Palsy and Corticobasal Degeneration; 16: Pick's Disease; 17: Argyrophilic Grain Disease

18: Parkinsonism-Dementia Complex of Guam19: Postencephalitic Parkinsonism; Part 4: Synucleinopathies; 20: Introduction to a-Synucleinopathies; 21: Parkinson's Disease; 22: Dementia with Lewy Bodies and Parkinson's Disease Dementia; 23: Lewy Bodies in Conditions other than Disorders of a-Synuclein; 24: Multiple System Atrophy; Part 5: Trinucleotide Repeat Disorders; 25: Introduction to Trinucleotide Repeat Diseases; 26: Huntington's Disease; 27: Spinocerebellar Ataxias; 28: Friedreich's Ataxia; 29: Dentatorubral- pallidoluysian Atrophy; 30: Spinal and Bulbar Muscular Atrophy

Part 6: Prion Disorders31: Introduction to Prion Disorders; 32: Sporadic Creutzfeldt-Jakob Disease; 33: Genetic Creutzfeldt-Jakob Disease; 34: Fatal Familial and Sporadic Insomnia; 35: A New Prion Disease: Protease -Sensitive Prionopathy; 36: Variant Creutzfeldt-Jakob Disease; 37: Gerstmann-Sträussler-Scheinker Disease; 38: Kuru; 39: Iatrogenic Creutzfeldt-Jakob Disease; Part 7: Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis/Motor Neuron Disease; 40: Introduction; 41: Frontotemporal Lobar Degeneration with TDP-43 Pathology

42: Neuronal Intermediate Filament Inclusion Disease43: Frontotemporal Lobar Degeneration with FUS Immunoreactive Inclusions; 44: Amyotrophic Lateral Sclerosis, Primary Lateral Sclerosis and Spinal Muscular Atrophy; Part 8: Other Neurodegenerative Disorders; 45: Introduction: Genetic Analysis as a Lumper and Splitter in Neurodegenerative Disease; 46: Inherited Amyloidoses and Neurodegeneration: Familial British Dementia and Familial Danish Dementia; 47: Neurodegeneration with Brain Iron Accumulation; 48: Familial Encephalopathy with Neuroserpin Inclusion Bodies

49: Hereditary Ferritinopathies

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

ISBN:

1-283-27412-4

9786613274120

1-4443-4125-1

1-4443-4122-7

OCLC:

758981654