Plasmid biopharmaceuticals : basics, applications, and manufacturing / Duarte Miguel F. Prazeres.

Format:

Book

Author/Creator:

Prazeres, Duarte Miguel F.

Language:

English

Subjects (All):

Plasmids.

Biopharmaceutics.

Physical Description:

1 online resource (612 p.)

Edition:

1st ed.

Place of Publication:

Hoboken, N.J. : John Wiley & Sons, c2011.

Language Note:

English

Summary:

The book addresses the basics, applications, and manufacturing of plasmid biopharmaceuticals. The survey of the most relevant characteristics of plasmids provides the basics for designing plasmid products (applications) and processes (manufacturing). Key features that the authors include in the book are: i) consistency and clear line of direction, ii) an extensive use of cross-referencing between the individual chapters, iii) a rational integration of chapters, iv) appellative figures, tables and schemes, and v) an updated, but selected choice of references, with a focus on key papers.

Contents:

Historical perspective

Gene transfer with plasmid biopharmaceuticals

Product and process development

Structure

Analytical characterization

Delivery

Ethical and safety issues

Human and veterinary markets

Human case studies : pandemic influenza and critical limb ischaemia

Veterinary case studies : West Nile, infectious hematopoietic necrosis, and melanoma

GMPS and validation

Product specifications and quality control

Cell culture

An overview of downstream processing

Primary isolation

Intermediate recovery

Final purification

Process synthesis

Concluding remarks and outlook.

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

Description based on metadata supplied by the publisher and other sources.

ISBN:

9786613239440

9781118002254

1118002253

9781283239448

1283239442

9780470939918

0470939915

9780470939871

0470939877

OCLC:

746321021