DNA deamination and the immune system : AID in health and disease / editors, Sebastian Fugmann, Marilyn Diaz, Nina Papavasiliou.

Format:

Book

Contributor:

Fugmann, Sebastian.

Diaz, Marilyn.

Papavasiliou, Nina.

Series:

Molecular medicine and medicinal chemistry ; v. 3.

Molecular medicine and medicinal chemistry ; v. 3

Language:

English

Subjects (All):

DNA.

Immune system.

Physical Description:

1 online resource (232 p.)

Edition:

1st ed.

Place of Publication:

London : Imperial College Press, 2011.

Language Note:

English

Summary:

This book covers the current understanding of the role of activation-induced cytidine deaminase (AID) in the generation of antibody response to antigenic challenge. Since the discovery of AID, and the genetic demonstration of its role in somatic hypermutation and class-switch recombination of antibody genes, much has been learned about the biochemistry of this enzyme. However, some key questions remain hotly contested, such as: how does this enzyme get to the antibody locus leaving the rest of the genome intact, and why are DNA repair pathways which normally repair deamination events co-opted

Contents:

Preface; Contents; List of Tables; List of Figures; Chapter 1 Introduction; Chapter 2 Switch Regions, ChromatinAccessibility and AID Targeting; Chapter 3 Cis-Regulatory Elements that Target AID to Immunoglobulin Loci; Chapter 4 Partners in Diversity: The Search for AID Co-Factors; Chapter 5 Resolution of AID Lesions in Class Switch Recombination; Chapter 6 Error-Prone and Error-Free Resolution of AID Lesions in SHM; Chapter 7 Regulatory Mechanisms of AID Function; Chapter 8 AID in Immunodeficiency and Cancer; Chapter 9 AID in Aging and in Autoimmune Disease; Index

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

ISBN:

9786613143440

9781283143448

1283143445

9781848165939

1848165935

OCLC:

738433271