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Applications of Toxicogenomics in Safety Evaluation and Risk Assessment.
- Format:
- Book
- Author/Creator:
- Boverhof, Darrell R.
- Language:
- English
- Subjects (All):
- Genetic toxicology.
- Health risk assessment.
- Risk Assessment.
- Toxicity testing.
- Toxicogenetics.
- Toxicology.
- Pharmacogenetics.
- Risk.
- Risk Management.
- Epidemiologic Measurements.
- Organization and Administration.
- Pharmacology.
- Probability.
- Genetics.
- Public Health.
- Health Occupations.
- Statistics as Topic.
- Biological Science Disciplines.
- Biology.
- Health Services Administration.
- Environment and Public Health.
- Natural Science Disciplines.
- Delivery of Health Care.
- Health Care Evaluation Mechanisms.
- Epidemiologic Methods.
- Quality of Health Care.
- Investigative Techniques.
- Health Care Quality, Access, and Evaluation.
- Medical Subjects:
- Toxicology.
- Pharmacogenetics.
- Risk.
- Risk Management.
- Epidemiologic Measurements.
- Organization and Administration.
- Pharmacology.
- Probability.
- Genetics.
- Public Health.
- Health Occupations.
- Statistics as Topic.
- Biological Science Disciplines.
- Biology.
- Health Services Administration.
- Environment and Public Health.
- Natural Science Disciplines.
- Delivery of Health Care.
- Health Care Evaluation Mechanisms.
- Epidemiologic Methods.
- Quality of Health Care.
- Investigative Techniques.
- Health Care Quality, Access, and Evaluation.
- Risk Assessment.
- Toxicogenetics.
- Local Subjects:
- Genetic toxicology.
- Health risk assessment.
- Risk Assessment.
- Toxicity testing.
- Toxicogenetics.
- Physical Description:
- 1 online resource (402 pages)
- Edition:
- First edition.
- Place of Publication:
- Hoboken : Wiley, 2011.
- Language Note:
- English
- Summary:
- This book provides a timely overview of toxicogenomics, with special emphasis on the practical applications of this technology to the risk assessment process. Introductory sections are followed by a series of chapters highlighting practical and systematic applications of toxicogenomics in informing the risk assessment process - including the areas of mutagenicity, carcinogenicity, endocrine toxicity, organ-specific toxicity, population monitoring, and ecotoxicology. The book concludes with approaches for the integration of this technology in safety evaluation studies, and an outlook on how tox
- Contents:
- Contents; Preface; Contributors; 1 Toxicology, ""Omics"" Technologies, and Toxicogenomics: A Primer; 2 Introduction to Human Health Risk Assessment; 3 Practical Considerations for the Application of Toxicogenomics to Risk Assessment: Early Experience, Current Drivers, and a Path Forward; 4 Approaches and Practical Considerations for the Analysis of Toxicogenomics Data; 5 Genomics in Identifying Mutagenic Mode of Action in Carcinogenesis; 6 Application of Genomics for Predicting and Understanding the Mode of Action for Nongenotoxic Carcinogens; 7 Genomics in Characterizing Endocrine Toxicity
- 8 Studying Organ-Specific Toxicity Using Gene-Expression Profiling9 Toxicogenomic Studies in Human Populations; 10 Toxicogenomics Applied to Ecological Risk Assessment; 11 Analysis of Transcriptomic Dose-Response Data for Toxicology and Risk Assessment; 12 Toxicogenomics as a Tool for Validating Animal to Human Extrapolations in Chemical Risk Assessment: Concepts, Applications, and Challenges; 13 Toxicogenomics and Animal Alternatives; 14 Toxicogenomics and the Regulatory Framework; 15 Standardization of Gene-Expression Information for the Safety Evaluation: Activities in Japan
- 16 Applying Transcriptional Profiling in Drug Safety Evaluation17 Reframing the Risk Assessment Paradigm: Toward a Systems Biology Approach; Index
- Notes:
- Description based upon print version of record.
- ISBN:
- 1-283-23966-3
- 9786613239662
- 1-118-00104-4
- 1-118-00103-6
- OCLC:
- 746321023
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