Hemodynamics and mechanobiology of endothelium / editors, Tzung K. Hsiai, Brett Blackman, Hanjoong Jo.

Format:

Book

Author/Creator:

Hsiai, Tzung K.

Contributor:

Hsiai, Tzung K.

Blackman, Brett.

Jo, Hanjoong.

Language:

English

Subjects (All):

Hemodynamics.

Oxidative stress.

Physical Description:

1 online resource (380 p.)

Edition:

1st ed.

Place of Publication:

Hackensack, N.J. : World Scientific, c2010.

Language Note:

English

Summary:

The book represents a paradigm shift from the traditional static model of investigation of oxidative biology to the dynamic model of vascular oxidative stress. The investigation of vascular biology and cardiovascular medicine is made possible by the use of tissue engineering, nanotechnology and stem cell research. This is the first textbook to target a wide readership from academia to industry and government agencies in the field of cardiovascular diseases.

Contents:

PREFACE; CONTENTS; Chapter 1 FLOW AND ATHEROSCLEROSIS; 1. Overview and Clinical Significance; 1.1. Composition and Progression of Atherosclerotic Plaques; 1.1.1. Early Lesions; 1.1.2. Advanced Lesions; 1.1.3. Outward Remodeling and Plaque Stenosis; 2. Methods for Studying the Role of Flow in the Pathogenesis of Atherosclerosis; 2.1. Tools for Studying Biological Responses to Mechanical Stimuli in Vitro; 2.2. Animal Models of Atherosclerosis and Relation to Flow; 2.2.1. Genetically-manipulated Mouse Models; 2.2.2. Mechanical Induction of Stenosis in Animals

2.2.3. Larger Animal Models of Atherosclerosis2.3. Flow in Humans and Its Role in Atherosclerosis; 2.4. Computational Fluid Dynamics; 2.4.1. Imaging Data for Lesion-specific Geometry; 2.4.2. Modeling Assumptions; 3. Wall Shear Stress is a Potent Modulator of Plaque Formation and Localization; 3.1. Low and Oscillatory Wall Shear Stress Promote Atherosclerotic Plaque Formation; 3.2. High Wall Shear Stress Protects Arteries from Atherosclerosis; 3.3. Hemodynamic Parameters Related to Plaque Formation; 3.4. Wall Shear Stress and Plaque Rupture

4. Flow is Not the Only Biomechanical Determinant of Plaque Formation and Disruption4.1. Solid Wall Mechanics and Atherosclerotic Responses to Stretch; 4.2. Plaque Composition Influences Solid Wall Mechanics and Risk for Rupture; 4.3. Fluid-solid Interaction Provides Additional Biomechanical Insight into Atherosclerosis; 5. Current Dilemmas and Future Directions for Atherosclerotic Research; 5.1. Need for Better Understanding of Plaque Disruption Events; 5.2. How Do Flow-mediated Mechanisms of Atherogenesis Occur on Human Timescales?

5.3. How Much Does Directionality of Flow Contribute to Atherosclerosis?6. Conclusion; References; Chapter 2 SHEAR STRESS-MEDIATED SIGNAL TRANSDUCTION; 1. Introduction; 2. Mechanosignal Transduction: From Molecular Sensors to Cellular Responses; 3. The Role of Mechanotransduction in Cardiovascular Health and Disease; 4. The Unique Role of PECAM-1 in Mechanosensing; 4.1. Forced-induced PECAM-1 Phosphorylation and Mechano-signaling; 4.2. PECAM-1 as a Mechanosensor; 4.3. PECAM-1 Kinase in Mechanotransduction; 5. S-flow-mediated Redox Regulation and Inflammation

5.1. TRX and TRX-interacting Protein (TXNIP)5.2. Thiol Regulation and Glutaredoxin; 6. S-flow Inhibits TNF-α Signaling by Multiple Mechanisms; 6.1. MAP Kinases in Response to s-flow and TNF-α; 6.2. S-flow Inhibits PKCζ Signaling in ECs; 6.3. S-flow Inhibits TNF-α-mediated SHP-2 Phosphatase Activity and MEKK3 Signaling; 6.4. ERK5 Inhibits TNF-α-mediated JNK Activation; 7. ERK5 and Shear Stress; 7.1. s-flow Mediated ERK5 Activation; 7.2. ERK5 in Diabetes: ERK5-SUMOylation; 7.2.1. SUMOylation; 7.2.2. ERK5-SUMOylation; Acknowledgments; References

Chapter 3 ENDOTHELIAL GLYCOCALYX STRUCTURE AND ROLE IN MECHANOTRANSDUCTION

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

ISBN:

9786613143792

9781283143790

1283143798

9789814280426

9814280429

OCLC:

738438405