Biomarkers : in medicine, drug discovery, and environmental health / edited by Vishal S. Vaidya, Joseph V. Bonventre.

Format:

Book

Contributor:

Vaidya, Vishal S.

Bonventre, Joseph V.

Language:

English

Subjects (All):

Biochemical markers.

Physical Description:

1 online resource (648 p.)

Edition:

1st ed.

Place of Publication:

Hoboken, N.J. : Wiley, c2010.

Language Note:

English

Summary:

"This book provides an introduction to the field of biomarkers, how they have been and can be used, and how different approaches can be used to identify, characterize, and monitor biomarkers. The book has chapters on topics including HIV, Cancer, Parkinson's, vascular injury, environmental exposure. A following section discusses the technologies (diagnostics and assays) to detect biomarkers and authors have emphasized the preclinical and clinical manifestation of the injury/disease process"--Provided by publisher.

Contents:

Biomarkers: In Medicine, Drug Discovery, and Environmental Health; CONTENTS; Preface; Contributors; 1 Biomarkers: An Evolutionary Perspective; SECTION I: TOOLS FOR BIOMARKER DISCOVERY; 2 Genomics; Introduction; Evaluation of the Technology; Clinical Applications; Bioinformatics Challenges; Applications to Drug Toxicology, Medicine, and Environmental Health; Improve Understanding of Basic Cellular Architecture and Function; Mechanism of Toxicity and Disease; Algorithmic Models to Predict Toxicity or Disease; Strengths, Weaknesses, and the Road Forward; Conclusion; Summary Points; Disclaimer

References3 Proteomics for Biomarker Discovery; Introduction; Tissue or Biofluid; Technology; Protein Identification Using Mass Spectrometry; Sample Preparation; Protein Quantitation; Examples of Biomarker Discovery and Evaluation; Challenges in Proteomic Biomarker Discovery; The Road Forward: Targeted Verification and Validation; Conclusion; Summary Points; Acknowledgments; References; 4 Metabolic Profiling for Biomarker Discovery; Introduction: What is Metabolic Profiling?; Analytical Strategies for Metabolic Profiling; Data Pre-Processing, Analysis, and Pattern Recognition

Preclinical Toxicology: Models for Pathological Biomarker DiscoveryDisease Biomarker Discovery Using Metabolic Profiling; Inborn Errors of Metabolism; Neuroscience; Cancer; Infectious Disease; Metabolic Syndrome: Insulin Resistance, Cardiovascular Disease, and Hypertension; Environmental Health and Metabolic Profiling; Conclusion: Strengths, Weaknesses, and the Way Forward for Metabolic Profiling in Biomarker Discovery; Summary Points; References; 5 The Bittersweet Promise of Glycobiology; Introduction; Glycosylation in Pathological States; Congenital Disorders of Glycosylation (CDG)

Glycomics of Immune DisordersGlycomics in Cancer; Other Acquired Diseases; Glycans in Therapeutics and as Therapeutic Targets; Tools to Analyze the Glycome; Analytical; Chemical; Microarray; Molecular; Strengths, Weaknesses, and the Road Forward; Conclusion; Summary Points; References; SECTION II: BIOMARKERS OF INJURY/DISEASE; 6 Biomarkers of Alzheimer's and Parkinson's Disease; Definition and Prevalence of Alzheimer's and Parkinson's Disease; Alzheimer's Disease; Parkinson's Disease; Pathophysiology and Mechanisms; Alzheimer's Disease; Genetic Aspects; Pathology

Pathophysiological MechanismsParkinson's Disease; Genetic Aspects; Pathology; Pathophysiological Mechanisms; Concluding Remarks to Pathological and Pathophysiological Aspects; Current Means for Diagnosis/Prognosis of the Diseases and Their Limitations; Alzheimer's Disease; Clinical Markers; Genetic Markers; In Vivo Markers from Pathology; Pathophysiological Mechanisms; Further Diagnostic Assessments; Parkinson's Disease; Clinical Markers; Genetic Markers; In Vivo Markers from Pathology; Pathophysiological Mechanisms; Further Diagnostic Assessments; Novel Biomarkers; Alzheimer's Disease

Clinical Markers

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

Description based on metadata supplied by the publisher and other sources.

ISBN:

9786612883750

9781282883758

1282883755

9780470918562

047091856X

9780470918555

0470918551

OCLC:

689994988