Solid state characterization of pharmaceuticals / editors, Richard A. Storey, Ingvar Ymén.

Format:

Book

Contributor:

Storey, Richard A.

Ymen, Ingvar.

Language:

English

Subjects (All):

Solid dosage forms.

Drugs--Design.

Drugs.

Pharmaceutical chemistry.

Physical Description:

1 online resource (528 pages)

Edition:

1st ed.

Place of Publication:

Chichester, U.K. : John Wiley & Sons, 2011.

Language Note:

English

Summary:

The field of solid state characterization is central to the pharmaceutical industry, as drug products are, in an overwhelming number of cases, produced as solid materials. Selection of the optimum solid form is a critical aspect of the development of pharmaceutical compounds, due to their ability to exist in more than one form or crystal structure (polymorphism). These polymorphs exhibit different physical properties which can affect their biopharmaceutical properties. This book provides an up-to-date review of the current techniques used to characterize pharmaceutical solids. Ensuring balan

Contents:

Introduction to the solid state : physical properties and processes

X-ray diffraction

Spectroscopic characterisation

Dielectric spectroscopy and thermally stimulated current spectroscopy : use in the characterisation of solid state pharmaceutical systems

Solid state characterisation of pharmaceuticals

Calorimetric methods : solution calorimetry

Vapour sorption for bulk and surface analysis

Microscopy

Mechanical properties of pharmaceutical materials

Particle size assessment

Computational polymorph prediction

Patenting of inventions relating to polymorphs

A 'roadmap' to solid form selection.

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

Description based on metadata supplied by the publisher and other sources.

ISBN:

9786613203465

9781283203463

1283203464

9781119970170

1119970172

9780470659359

0470659351

9780470656792

0470656794

OCLC:

711780324