Toxicity-pathway-based risk assessment : preparing for paradigm change : a symposium summary / Ellen Mantus ; Standing Committee on Risk Analysis Issues and Reviews, Board on Environmental Studies and Toxicology, Division on Earth and Life Studies.

Format:

Book

Author/Creator:

National Research Council (U.S.).

Contributor:

Mantus, Ellen.

Standing Committee on Risk Analysis Issues and Reviews.

Board on Environmental Studies and Toxicology.

Division on Earth and Life Studies.

Language:

English

Subjects (All):

Toxicity testing.

Physical Description:

1 online resource (135 p.)

Edition:

1st ed.

Place of Publication:

Washington, D.C. : National Academies Press, 2010.

Language Note:

English

Summary:

In 2007, the National Research Council envisioned a new paradigm in which biologically important perturbations in key toxicity pathways would be evaluated with new methods in molecular biology, bioinformatics, computational toxicology, and a comprehensive array of in vitro tests based primarily on human biology. Although some considered the vision too optimistic with respect to the promise of the new science, no one can deny that a revolution in toxicity testing is under way. New approaches are being developed, and data are being generated. As a result, the U.S. Environmental Protection Agency (EPA) expects a large influx of data that will need to be evaluated. EPA also is faced with tens of thousands of chemicals on which toxicity information is incomplete and emerging chemicals and substances that will need risk assessment and possible regulation. Therefore, the agency asked the National Research Council to convene a symposium to stimulate discussion on the application of the new approaches and data in risk assessment. The symposium was held on May 11-13, 2009, in Washington, DC, and included presentations and discussion sessions on pathway-based approaches for hazard identification, applications of new approaches to mode-of-action analyses, the challenges to and opportunities for risk assessment in the changing paradigm, and future directions.

Contents:

""Front Matter""; ""Preface""; ""Contents""; ""Summary of the Symposium""; ""Appendixes""; ""Appendix A: Biographic Information on the Standing Committee on Risk Analysis Issues and Reviews""; ""Appendix B: Biographic Information on the Planning Committee for a Symposium on Toxicity-Pathway-Based Risk Assessment""; ""Appendix C: Symposium Agenda""; ""Appendix D: Biographic Information on the Speakers and Panelists for a Symposium on Toxicity-Pathway-Based Risk Assessment""; ""Appendix E: Symposium Presentations""; ""Appendix F: Poster Abstracts""

Notes:

Description based upon print version of record.

ISBN:

9786612660443

9780309156929

0309156920

9781282660441

1282660446

9780309154239

0309154235

OCLC:

657413889