Reproductive and developmental toxicology / edited by Ramesh C. Gupta.

Format:

Book

Contributor:

Gupta, Ramesh C. (Ramesh Chandra), 1949-

Language:

English

Subjects (All):

Developmental toxicology.

Reproductive toxicology.

Physical Description:

1 online resource (1243 p.)

Edition:

1st ed.

Place of Publication:

Amsterdam ; Boston : Elsevier, 2011.

Language Note:

English

Summary:

Reproductive toxicology is a complex subject dealing with three components-parent, placenta, and fetus-and the continuous changes that occur in each. Reproductive and Developmental Toxicology is a comprehensive and authoritative resource providing the latest literature enriched with relevant references describing every aspect of this area of science. It addresses a broad range of topics including nanoparticles and radiation, gases and solvents, smoking, alcohol and drugs of abuse, food additives, nutraceuticals and pharmaceuticals, and metals, among others. With a special focus on pl

Contents:

Front Cover; Dedication; Reproductive And Developmental Toxicology; Copyright; Contents; Foreword; List of Contributors; Section 1 - General; Chapter 1 - Introduction; Introduction; Chapter 2 - Reproductive anatomy and physiology; Introduction; Important definitions and concepts; Review of normal human reproduction; Concluding remarks and future directions; References; Chapter 3 - Bio-communication between mother and offspring; Introduction; Maternal influences on the development of the offspring; Transportation of bioactive substances between mother and offspring

Concluding remarks and future directionsReferences; Chapter 4 - Pharmacokinetics in pregnancy; Introduction; Factors affecting pharmacokinetics in pregnancy; The fetal compartment; Maternal disease and obstetrical complications; Origins of the knowledge gap; Concluding remarks, current initiatives and future directions; References; Chapter 5 - PBPK models in reproductive and developmental toxicology; Introduction; PBPK Modeling: basic concepts and tools; PBPK Modeling in reproductive and developmental toxicology; PBPK Model applications in reproductive and developmental toxicology

Concluding remarks and future directionsReferences; Chapter 6 - Transfer of drugs and xenobiotics through milk; Introduction; Drug excretion into breast milk; Drug disposition in the infant; Drugs that should be used with caution; Non-medicinal substances; Environmental pollutants; Concluding remarks and future directions; Acknowledgment; References; Section 2 - Safety Evaluation andToxicity Testing Models; Chapter 7 - Postmarket surveillance and regulatory considerations in reproductive and developmental toxicology: an FDA perspective; Introduction; Drugs intended for use in humans

Vaccines intended for use in humansDrugs intended for use in animals; References; Chapter 8 - Reproductive and developmental safety evaluation of new pharmaceutical compounds; Introduction; Overview Of Human Pharmaceutical Development Process; Developmental And Reproductive Toxicity (Dart) Studies Needed For Development Of Innovative Human Pharmaceuticals; Interpretation Of Human Risk From The Reproductive And Developmental Toxicity Studies In Animals; Reproductive Risks Communication And Management; Concluding Remarks And Future Directions; References

Chapter 9 - Relevance of animal testing and sensitivity of endpoints in reproductive and developmental toxicityIntroduction; Choice of animal test models; Non-mammalian animal models; Endpoints of reproductive toxicity; Tests and test guidelines; Types of studies; The path to alternative tests and conclusions; References; Chapter 10 - OECD guidelines and validated methods for in vivo testing of reproductive toxicity; Introduction; Method OECD 414 (prenatal developmental toxicity); Method OECD 415 (One-generation reproduction toxicity study)

Method OECD 416 (two-generation reproduction toxicity study)

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

ISBN:

1-282-99423-9

9786612994234

0-12-382033-2

OCLC:

709551267