Diagnostic pediatric hematopathology / edited by Maria A. Proytcheva.

Format:

Book

Contributor:

Proytcheva, Maria A., editor.

Language:

English

Subjects (All):

Pediatric hematology.

Blood--Diseases--Diagnosis.

Blood.

Children--Diseases--Diagnosis.

Children.

Physical Description:

1 online resource (xi, 577 pages) : digital, PDF file(s).

Edition:

1st ed.

Place of Publication:

Cambridge : Cambridge University Press, 2011.

Language Note:

English

Summary:

Diagnostic Pediatric Hematopathology is unique in providing an accurate and up-to-date guide to the diagnosis of benign and malignant hematologic disorders of childhood. The text discusses the development of the hematopoietic and lymphoid systems - and how this affects normal and abnormal findings in children at various ages. Also examined are the morphologic, immunophenotypic, cytogenetic, and molecular genetic characteristics of most pediatric-specific hematologic diseases. This is an excellent reference that ensures accurate diagnoses when evaluating peripheral blood, bone marrow, and lymph nodes of children. The text is written by a team of experienced pediatric hematopathologists and clinical scientists drawn from major academic children's hospitals in the United States, Europe, and Canada. It will be a valuable tool in the every day practice of pathologists, pediatric pathologists, and hematopathologists, and a ready educational resource for fellows, pathology residents, medical students, clinical scientists in the field, and pediatric hematologists/oncologists.

Contents:

Cover; Diagnostic Pediatric Hematopathology; Title; Copyright; Dedication; Contents; Contributors; Acknowledgements; Introduction; Section 1: General and non-neoplastic hematopathology; Chapter 1: Hematologic values in the healthy fetus, neonate, and child; Developmental hematopoiesis: a general view; Composition of fetal blood; Hematologic values in term neonates and infants; Hematologic values in small-for-gestational-age (SGA) term newborns; Hematologic values in preterm neonates; Hematologic values during early childhood and in older children

Preanalytical issues related to pediatric blood samplesLimited blood availability; Effect of blood sampling site on the hematology test results; Effect of exertion and violent crying on the white blood cell count; Other preanalytical factors affecting hematologic test results in neonates; Analytical issues related to pediatric blood samples; Interpretation of hematologic test results in children; Other factors affecting neonatal testing; Chapter 2: Normal bone marrow; Ontogeny of the hematopoietic system; Postnatal bone marrow; Age-specific differences in the bone marrow

Bone marrow examination in childrenReferences; Chapter 3: Disorders of erythrocyte production: Nutritional deficiencies, iron deficient, and sideroblastic anemia; Introduction; Iron; Dietary iron; Iron transport; Iron uptake from the intestine; Iron uptake from the plasma; Iron storage; Iron regulation; Hemoglobin synthesis; Age and iron needs; Iron in the first year; Iron in the diet; Assessment of iron status; Ferritin; Serum iron and transferrin; Zinc protoporphyrin; Soluble transferrin receptor; Treatment of iron deficiency; Vitamin B12; Role in the body; Dietary vitamin B12

Vitamin B12 absorption and metabolismVitamin B12 deficiency; Maternal vitamin B12 deficiency; Inherited disorders of transport and absorption of vitamin B12; Inborn errors of metabolism; Methylmalonyl-CoA mutase deficiency; Adenosylcobalamin deficiency; Methylcobalamin deficiency; Combined deficiencies; Acquired vitamin B12 deficiency; Assessment; Treatment; Folate; Role in the body; Dietary folate and folic acid; Folate absorption and metabolism; Folate deficiency; Pregnancy; Malabsorption; Increased utilization of folate; Drugs; Inherited disorders of transport and metabolism; Assessment

TreatmentSideroblastic anemia; References; Chapter 4: Disorders of hemoglobin synthesis: Thalassemias and structural hemoglobinopathies; Normal hemoglobins; Structure and function of hemoglobin; Genetics and transcription control of hemoglobin; Disorders of hemoglobin synthesis; Overview; Population genetics; Thalassemias; Alpha-thalassemias; Beta-thalassemias; Delta-beta-thalassemias; Structural hemoglobinopathies; Hemoglobin S; Hemoglobin C, hemoglobin D, and other rare hemoglobinopathies; Interactions of structural hemoglobinopathies with thalassemias; Laboratory evaluation; Introduction

Effects of hemoglobinopathies on general laboratory tests

Notes:

Title from publisher's bibliographic system (viewed on 05 Oct 2015).

Includes bibliographical references and index.

ISBN:

1-107-21901-9

1-280-77582-3

0-511-91811-9

9786613686213

0-511-91713-9

0-511-91909-3

0-511-78129-6

0-511-91532-2

OCLC:

784881172