Gene discovery for disease models / edited by Weikuan Gu.

Format:

Book

Contributor:

Gu, Weikuan.

Language:

English

Subjects (All):

Medical genetics.

Mutation (Biology).

Genomics.

Genetic disorders.

Physical Description:

1 online resource (569 p.)

Edition:

1st ed.

Place of Publication:

Hoboken, N.J. : Wiley, c2011.

Language Note:

English

Summary:

This book provides readers with new paradigms on the mutation discovery in the post-genome era. The completion of human and other genome sequencing, along with other new technologies, such as mutation analysis and microarray, has dramatically accelerated the progress in positional cloning of genes from mutated models. In 2002, the Mouse Genome Sequencing Consortium stated that "The availability of an annotated mouse genome sequence now provides the most efficient tool yet in the gene hunter's toolkit. One can move directly from genetic mapping to identification of candidate genes, and the expe

Contents:

Introduction : gene discovery-from positional cloning to genomic cloning

High throughput gene expression analysis and the identification of expression QTLs

DNA methylation in the pathogenesis of autoimmunity

Ccell-based analysis with microfluidic chip

Missing dimension : protein turnover rate measurement in gene discovery

Bioinformatics tools for the prediction of gene function

Determination of genomic locations of targeted genetic loci

Mutation discovery using high throughput mutation screening technology

Candidate screening through gene expression profile

Candidate screening through high-density SNP array

Gene discovery through direct genome sequencing

Candidate screening through bioinformatics tools

Using an integrative strategy to identify mutations

Determination of the function of a mutant in a gene

Confirmation of a mutation by multiple molecular approaches

Confirmation of a mutation by microRNA

Confirmation of function of a gene by translational approaches

Confirmation of single nucleotide mutations

Initial identification and confirmation of a QTL gene

Gene discovery of crop diseases in the post genome era

Impact of whole genome genetic element analysis on gene discovery of disease models

Impact of whole genome protein analysis on gene discovery of disease models.

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

Description based on metadata supplied by the publisher and other sources.

ISBN:

9786612989742

9781118002179

1118002172

9781282989740

128298974X

9780470933947

0470933941

9780470933930

0470933933

OCLC:

708563222