Metabolic syndrome : underlying mechanisms and drug therapies / edited by Minghan Wang.

Format:

Book

Contributor:

Wang, Minghan, 1966-

Language:

English

Subjects (All):

Metabolic syndrome--Pathophysiology.

Metabolic syndrome.

Metabolic syndrome--Chemotherapy.

Physical Description:

1 online resource (510 p.)

Edition:

1st ed.

Place of Publication:

Hoboken, N.J. : John Wiley & Sons, c2011.

Language Note:

English

Summary:

This book provides a comprehensive overview of the development of metabolic syndrome, the underlying mechanisms and therapeutic strategies for drug development. The authors examine the context of underlying molecular pathways and integrated physiology, then expanding the discussion to diseases associated with metabolic syndrome. The development of drug therapies for these diseases and complications is extensively covered. The book offers a comprehensive and in-depth view of energy metabolism, metabolic tissues and pathways, molecular mechanism-based drug discovery and clinical implications.

Contents:

Gut as an endocrine organ : the role of nutrient-sensing in energy metabolism / Minghan Wang

Central glucose sensing and control of food intake and energy homeostasis / Lourdes Mounien and Bernard Thorens

Abnormalities in insulin secretion in type 2 diabetes mellitus / Taly Meas and Pierre-Jean Guillausseau

Adipokine production by adipose tissue : a novel target for treating metabolic syndrome and its sequelae / Vanessa DeClercq ... [et al.]

Hepatic metabolic dysfunctions in type 2 diabetes : insulin resistance and impaired glucose production and lipid synthesis / Ruojing Yang

Energy metabolism in skeletal muscle and its link to insulin resistance / Minghan Wang

Mechanisms and complications of metabolic syndrome / Minghan Wang

Emerging therapeutic approaches for dyslipidemia associated with high LDL and low HDL / Margrit Schwarz and Jae B. Kim

Mechanism of action of niacin : implications for atherosclerosis and drug discovery / Devan Marar ... [et al.]

Current anti-diabetic therapies and mechanisms / Minghan Wang

GLP-1 biology, signaling mechanisms, physiology, and clinical studies / Remy Burcelin ... [et al.]

Dipeptidyl peptidase IV inhibitors for treatment of diabetes / McIntosh, C.H.S. ... [et al.]

Sodium glucose co-transporter 2 inhibitors / Margaret Ryan and Serge A. Jabbour

Fibroblast growth factor 21 as a novel metabolic regulator / Radmila Micanovic, James D. Dunbar, and Alexei Kharitonenkov

Sirtuins as potential drug targets for metabolic diseases / Qiang Tong

11-hydroxysteroid dehydrogenase type 1 as a therapeutic target for type 2 diabetes / Clarence Hale and David J. St. Jean, Jr

Monoclonal antibodies for the treatment of type 2 diabetes : a case study with glucagon receptor blockade / Hai Yan, Wei Gu, and Murielle Veniant-Ellison

Drug development for metabolic diseases: past, present and future / Minghan Wang.

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

Description based on metadata supplied by the publisher and other sources.

ISBN:

9786612888984

9780470922712

0470922710

9781282888982

1282888986

9780470910016

0470910011

9780470910009

0470910003

OCLC:

696237308