Lab-on-a-chip : techniques, circuits, and biomedical applications / Yahya H. Ghallab, Wael Badawy.

Format:

Book

Author/Creator:

Ghallab, Yehya H.

Contributor:

Badawy, Wael.

Series:

Artech House integrated microsystems series.

Artech House integrated microsystems series

Language:

English

Subjects (All):

Microelectromechanical systems.

Chemical laboratories--Electronic equipment.

Chemical laboratories.

Biomedical engineering.

Physical Description:

1 online resource (238 p.)

Edition:

1st ed.

Place of Publication:

Norwood, MA : Artech House, c2010.

Language Note:

English

Summary:

"Here's a groundbreaking book that introduces and discusses the important aspects of lab-on-a-chip, including the practical techniques, circuits, microsystems, and key applications in the biomedical, biology, and life science fields. Moreover, this volume covers ongoing research in lab-on-a-chip integration and electric field imaging. Presented in a clear and logical manner, the book provides you with the fundamental underpinnings of lab-on-a-chip, presents practical results, and brings you up to date with state-of-the-art research in the field. This unique resource is supported with over 160 illustrations that clarify important topics throughout."--Publisher's description.

Contents:

1. Introduction to Lab-on-a-Chip

1.1. History

1.2. Parts and Components of Lab-on-a-Chip

1.2.1. Electric and Magnetic Actuators

1.2.2. Electrical Sensors

1.2.3. Thermal Sensors

1.2.4. Optical Sensors

1.2.5. Microfluidic Chambers

1.3. Applications of Lab-on-a-Chip

1.4. Advantages and Disadvantages of Lab-on-a-Chip

References

2. Cell Structure, Properties, and Models

2.1. Cell Structure

2.1.1. Prokaryotic Cells

2.1.2. Eukaryotic Cells

2.1.3. Cell Components

2.2. Electromechanics of Particles

2.2.1. Single-Layer Model

2.2.2. Double-Layer Model

2.3. Electrogenic Cells

2.3.1. Neurons

2.3.2. Gated Ion Channels

2.3.3. Action Potential

3. Cell Manipulator Fields

3.1. Electric Field

3.1.1. Uniform Electric Field (Electrophoresis)

3.1.2. Nonuniform Electric Field (Dielectrophoresis)

3.2. Magnetic Field

3.2.1. Nonuniform Magnetic Field (Magnetophoresis)

3.2.2. Magnetophoresis Force (MAP Force)

4. Metal-Oxide Semiconductor (MOS) Technology Fundamentals

4.1. Semiconductor Properties

4.2. Intrinsic Semiconductors

4.3. Extrinsic Semiconductor

4.3.1. N-Type Doping

4.3.2. P-Type Doping

4.4. MOS Device Physics

4.5. MOS Characteristics

4.5.1. Modes of Operation

4.6. Complementary Metal-Oxide Semiconductor (CMOS) Device

4.6.1. Advantages of CMOS Technology

5. Sensing Techniques for Lab-on-a-Chip

5.1. Optical Technique

5.2. Fluorescent Labeling Technique

5.3. Impedance Sensing Technique

5.4. Magnetic Field Sensing Technique

5.5. CMOS AC Electrokinetic Microparticle Analysis System

5.5.1. Bioanalysis Platform

5.5.2. Experimental Tests

6. CMOS-Based Lab-on-a-Chip

6.1. PCB Lab-on-a-Chip for Micro-Organism Detection and Characterization

6.2. Actuation

6.3. Impedance Sensing

6.4. CMOS Lab-on-a-Chip for Micro-Organism Detection and Manipulation

6.5. CMOS Lab-on-a-Chip for Neuronal Activity Detection

6.6. CMOS Lab-on-a-Chip for Cytometry Applications

6.7. Flip-Chip Integration

7. CMOS Electric-Field-Based Lab-on-a-Chip for Cell Characterization and Detection

7.1. Design Flow

7.2. Actuation

7.3. Electrostatic Simulation

7.4. Sensing

7.5. The Electric Field Sensitive Field Effect Transistor (eFET)

7.6. The Differential Electric Field Sensitive Field Effect Transistor (DeFET)

7.7. DeFET Theory of Operation

7.8. Modeling the DeFET

7.8.1. A Simple DC Model

7.8.2. SPICE DC Equivalent Circuit

7.8.3. AC Equivalent Circuit

7.9. The Effect of the DeFET on the Applied Electric Field Profile

8. Prototyping and Experimental Analysis

8.1. Testing the DeFET

8.1.1. The DC Response

8.1.2. The AC (Frequency) Response

8.1.3. Other Features of the DeFET

8.2. Noise Analysis

8.2.1. Noise Sources

8.2.2. Noise Measurements

8.3. The Effect of Temperature and Light on DeFET Performance

8.4. Testing the Electric Field Imager

8.4.1. The Response of the Imager Under Different Environments

8.4.2. Testing the Imager with Biocells

8.5. Packaging the Lab-on-a-Chip

9. Readout Circuits for Lab-on-a-Chip

9.1. Current-Mode Circuits

9.2. Operational Floating Current Conveyor (OFCC)

9.2.1. A Simple Model

9.2.2. OFCC with Feedback

9.3. Current-Mode Instrumentation Amplifier

9.3.1. Current-Mode Instrumentation Amplifier (CMIA) Based on CCII

9.3.2. Current-Mode Instrumentation Amplifier Based on OFCC

9.4. Experimental and Simulation Results of the Proposed CMIA

9.4.1. The Differential Gain Measurements

9.4.2. Common-Mode Rejection Ratio Measurements

9.4.3. Other Features of the Proposed CMIA

9.4.4. Noise Results

9.5. Comparison Between Different CMIAs

9.6. Testing the Readout Circuit with the Electric Field Based Lab-on-a-Chip

10. Current-Mode Wheatstone Bridge for Lab-on-a-Chip Applications

10.1. Introduction

10.2. CMWB Based on Operational Floating Current Conveyor

10.3. A Linearization Technique Based on an Operational Floating Current Conveyor

10.4. Experimental and Simulation Results

10.4.1. The Differential Measurements

10.4.2. Common-Mode Measurements

10.5. Discussion

11. Current-Mode Readout Circuits for the pH Sensor

11.1. Introduction

11.2. Differential ISFET-Based pH Sensor

11.2.1. ISFET-Based pH Sensor

11.2.2. Differential ISFET Sensor

11.3. pH Readout Circuit Based on an Operational Floating Current Conveyor

11.3.1. Simulation Results

11.4. pH Readout Circuit Using Only Two Operational Floating Current Conveyors

11.4.1. Simulation Results

References.

Notes:

Description based upon print version of record.

Print version record.

Includes bibliographic references and index.

ISBN:

1-5231-1735-4

1-59693-419-0

OCLC:

796382972