Molecular imaging : principles and practice / [edited by] Ralph Weissleder ... [et al.].

Format:

Book

Contributor:

Weissleder, Ralph.

Language:

English

Subjects (All):

Molecular probes.

Diagnostic imaging.

Radioisotope scanning.

Imaging systems in medicine.

Physical Description:

1 online resource (1379 p.)

Edition:

1st ed.

Place of Publication:

Shelton, Conn. : People's Medical Pub. House, 2009.

Language Note:

English

Summary:

Over the last decade, the field of molecular imaging of living subjects has evolved considerably and has seen spectacular advances in chemistry, engineering, and biomedical applications. In a relatively short period of time, comprehensive molecular imaging centers have been established in the US, Europe and Asia and are increasingly integrated into basic sciences and translational networks. New investigators, collaborators, and students drawn into this multidisciplinary field have often expressed the desire and need for an authoritative textbook. This textbook was designed precisely to fill this need. Given the multidisciplinary nature of the field, the book is broken into six different sections. Part 1 (Molecular Imaging Technologies) summarizes the different macro-, meso-, and microscopic imaging technologies currently available. Part 2 (Chemistry of Melecular Imaging) is dedicated to reviewing chemical approaches to imaging probe designs for different types of imaging technologies. This section also contains chapters on the emerging field of nanomaterials, chemical biology, and probe design as well as signal amplification strategies. Part 3 (Molecular Imaging in Cell and Molecular Biology) contains chapters dedicated to protein engineering, vectors, and pathways. Part 4 (Applications of Molecular Imaging) summarizes the above advances in different clinical disease entities. Part V (Molecular Imaging in Drug Evaluation) is dedicated to imaging in drug development, and Part IV provides chapters on computation, bioinformatics, and modeling.

Contents:

""Front matter ""; ""Contents""; ""1: General Principles of Molecular Imaging ""; ""2: Imaging of Structure and Function with PET/CT ""; ""3: PET/MRI ""; ""4: SPECT and SPECT/CT ""; ""5: Principles of Micro X-Ray Computed Tomography ""; ""6: Small Animal SPECT, SPECT/CT, and SPECT/MRI ""; ""7: Instrumentation and Methods to Combine Small Animal PET with Other Imaging Modalities ""; ""8: Functional Imaging Using Bioluminescent Markers ""; ""9: Optical Multimodality Technologies ""; ""10: Fiber Optic Fluorescence Imaging ""; ""11: Fluorescence Tomography ""; ""12: Endomicroscopy ""

""13: Intravital Microscopy """"14: Diffuse Optical Tomography and Spectroscopy ""; ""15: Ultrasound ""; ""16: Molecular Photoacoustic Tomography ""; ""17: Optical Projection Tomography ""; ""18: Potential Roles for Retrospective Registration in Molecular Imaging ""; ""19: Chemistry of Molecular Imaging: An Overview ""; ""20: Radiochemistry of PET ""; ""21: Radiochemistry of SPECT: Examples of 99MTc and 111In Complexes ""; ""22: Nanochemistry for Molecular Imaging ""; ""23: Newer Bioconjugation Methods ""; ""24: Targeted Antibodies and Peptides ""

""25: Hyperpolarized 13C Magnetic Resonance Imaging - Principles and Applications """"26: Magnetic Resonance Imaging Agents ""; ""27: Optical Imaging Agents ""; ""28: Ultrasound Contrast Agents ""; ""29: Multimodality Agents ""; ""30: ""Click Chemistry"": Applications to Molecular Imaging""; ""31: The ""One-Bead-One-Compound"" Combinatorial Approach to Identifying Molecular Imaging Probes ""; ""32: Chemical Biology Approaches to Molecular Imaging""; ""33: Theranostics: Agents for Diagnosis and Therapy ""; ""34: Magnetic Nanoparticles ""

""35: Fluorocarbon Agents for Quantitative Multimodal Molecular Imaging and Targeted Therapeutics """"36: Aptamers for Molecular Imaging ""; ""37: Nonclinical Product Developmental Strategies...""; ""38: Overview of Molecular and Cell Biology ""; ""39: Systems Biology ""; ""40: Protein Engineering for Molecular Imaging""; ""41: Phage Display for Imaging Agent Development ""; ""42: Molecular Imaging of Gene Therapy ""; ""43: Developing Diagnostic and Therapeutic Viral Vectors ""; ""44: Cell Voyeurism Using Magnetic Resonance Imaging ""; ""45: Tumor Vasculature ""; ""46: Imaging Hypoxia ""

""47: Molecular Imaging of Protein-Protein Interactions """"48: Fluorescence Readouts of Biochemistry in Live Cells and Organisms ""; ""49: Imaging of Signaling Pathways ""; ""50: Molecular and Functional Imaging of the Tumor Microenvironment ""; ""51: Novel MR and PET Imaging in the RT Planning and Assessment of Response of Malignant Gliomas""; ""52: PET Diagnosis and Response Monitoring in Oncology ""; ""53: Magnetic Resonance Spectroscopy Treatment Response and Detection ""; ""54: Diffusion MRI: A Biomarker for Early Cancer Treatment Response Assessment ""; ""55: Myocardial Metabolism ""

""56: Congestive Heart Failure ""

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

ISBN:

1-60795-123-1

OCLC:

923337469