Antimicrobial activity of lactoferrin and lactoferrin derived peptides / Håvard Jenssen.

Format:

Book

Author/Creator:

Jenssen, Håvard.

Language:

English

Subjects (All):

Lactoferrin--Physiological effect.

Lactoferrin.

Lactoferrin--Derivatives--Physiological effect.

Anti-infective agents.

Physical Description:

1 online resource (112 p.)

Edition:

1st ed.

Place of Publication:

New York. : Nova Science Publishers, 2009.

Language Note:

English

Summary:

Milk is a vital nutritional source for offspring of all mammals, including humans. In addition to its nutritional value it is a rich source of proteins, of which lactoferrin (Lf) is one. Lf is truly a multifunctional molecule which has been studied extensively over the past decades. It is best known for its ability to bind iron, which initially leads to the discovery of its antibacterial activity. In addition, Lf has demonstrated potent antiviral, antifungal and antiparasitic activity, towards a spectrum of strains. Additionally, it has been evaluated as an important host defense molecule during infant development. Extensive work has been done to characterize the active domains in Lf, testing numerous Lf-derived peptides and related peptide libraries for activity towards different microbes. The peptides structural requirements for antimicrobial activity has been addressed, and compared to other cationic host defense peptides which related chemical and biological characteristics, in an attempt to understand different antimicrobial modes of action. The antimicrobial activity of Lf and one N-terminal peptide fragment of Lf (lactoferricin) are the main topics of this book, with particular focus on antiviral activities. Antibacterial, âe"fungal and âe"parasitic activities are discussed, in addition to the selective activity demonstrated by Lf and lactoferricin, towards tumor cell membranes. It has also become increasingly recognized that several antimicrobial protein and peptides possesses immunomodulatory activity, thus these properties are discussed in brief detail.

Contents:

Antiviral activity of LF

Antiviral activity of LF derived peptides

Antibacterial activity of LF

Antibacterial activity of LFCIN

Antifungal activity of LF

Antifungal activity of LFCIN

Antiparasitic activity of LF

Antiparasitic activity of LFCIN

Antitumor activity of LF

Antitumor activity of LFCIN

Novel applications and clinical use of LF and LF-derived peptides.

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

Description based on print version record and CIP data provided by publisher.

ISBN:

1-61728-137-9

OCLC:

659561210