Modern genome annotation : the BioSapiens Network / Dmitrij Frishman, Alfonso Valencia, editors.

Format:

Book

Contributor:

Frishman, Dmitrij.

Valencia, Alfonso.

Language:

English

Subjects (All):

Bioinformatics.

Human genome.

Physical Description:

1 online resource (506 p.)

Edition:

1st ed. 2008.

Place of Publication:

Wien ; New York : Springer, c2009.

Language Note:

English

Summary:

An accurate description of current scientific developments in the field of bioinformatics and computational implementation is presented by research of the BioSapiens Network of Excellence. Bioinformatics is essential for annotating the structure and function of genes, proteins and the analysis of complete genomes and to molecular biology and biochemistry. Included is an overview of bioinformatics, the full spectrum of genome annotation approaches including; genome analysis and gene prediction, gene regulation analysis and expression, genome variation and QTL analysis, large scale protein annotation of function and structure, annotation and prediction of protein interactions, and the organization and annotation of molecular networks and biochemical pathways. Also covered is a technical framework to organize and represent genome data using the DAS technology and work in the annotation of two large genomic sets: HIV/HCV viral genomes and splicing alternatives potentially encoded in 1% of the human genome.

Contents:

BIOSAPIENS: A European Network of Excellence to develop genome annotation resources

BIOSAPIENS: A European Network of Excellence to develop genome annotation resources

Gene definition

State of the art in eukaryotic gene prediction

Quality control of gene predictions

Gene regulation and expression

Evaluating the prediction of cis-acting regulatory elements in genome sequences

A biophysical approach to large-scale protein-DNA binding data

From gene expression profiling to gene regulation

Annotation and genetics

Annotation, genetics and transcriptomics

Functional annotation of proteins

Resources for functional annotation

Annotating bacterial genomes

Data mining in genome annotation

Modern genome annotation: the BioSapiens network

Structure to function

Harvesting the information from a family of proteins

Protein structure prediction

Structure prediction of globular proteins

The state of the art of membrane protein structure prediction: from sequence to 3D structure

Protein-protein complexes, pathways and networks

Computational analysis of metabolic networks

Protein-protein interactions: analysis and prediction

Infrastructure for distributed protein annotation

Applications

Viral bioinformatics

Alternative splicing in the ENCODE protein complement.

Notes:

Description based upon print version of record.

Includes bibliographical references.

ISBN:

1-282-50900-4

9786612509001

3-211-75123-8

OCLC:

728699606