Fundamentals of inflammation / edited by Charles N. Serhan, Peter A. Ward, Derek W. Gilroy.

Format:

Book

Contributor:

Serhan, Charles N., editor.

Ward, Peter A., 1934- editor.

Gilroy, Derek W., editor.

Language:

English

Subjects (All):

Inflammation.

Physical Description:

1 online resource (xiv, 473 pages) : digital, PDF file(s).

Edition:

1st ed.

Place of Publication:

Cambridge : Cambridge University Press, 2010.

Language Note:

English

Summary:

The acute inflammatory response is the body's first system of alarm signals that are directed toward containment and elimination of microbial invaders. Uncontrolled inflammation has emerged as a pathophysiologic basis for many widely occurring diseases in the general population that were not initially known to be linked to the inflammatory response, including cardiovascular disease, asthma, arthritis, and cancer. To better manage treatment, diagnosis, and prevention of these wide-ranging diseases, multidisciplinary research efforts are underway in both academic and industry settings. This book provides an introduction to the cell types, chemical mediators, and general mechanisms of the host's first response to invasion. World-class experts from institutions around the world have written chapters for this introductory text. The text is presented as an introductory springboard for graduate students, medical scientists, and researchers from other disciplines wishing to gain an appreciation and working knowledge of current cellular and molecular mechanisms fundamental to inflammation.

Contents:

Inflammatory response: an overview

Acute inflammation and chronic inflammation / Peter A. Ward

Resolution of acute inflammation and wound healing / Derek W. Gilroy

Links between innate and adaptive immunity / Christopher L. Karp

Individual Cell Types

Neutrophils I / Jose U. Scher, Steven B Abramson, and Michael H. Pillinger

Neutrophils II / Marco A. Cassatella

Mast cells as sentinels of inflammation / Joshua A. Boyce

Basophils / Jonathan Arm and David Sloane

Eosinophils / Sophie Fillon, Steven J. Ackerman, and Glenn T. Furuta

Macrophages / Sarah Fox and Adriano G. Rossi

Lymphocytes / Tracy Hussell

Fibroblasts and stromal cells / Andrew Filer and Christopher D. Buckley

Neutrophil-endothelial cell interactions / János G. Filep and Sean P. Colgan

Chemical Mediators

Lipid mediators in acute inflammation and resolution: eicosanoids, PAF, resolvins and protectins / Charles Serhan and Jesper Z. Haeggström

Cytokines and chemokines / IL-1 family in inflammation Nick Lukacs

Adenosine receptors: therapeutic aspects for inflammatory and immune diseases / György Haskó and Bruce Cronstein

Leukocyte generation of reactive oxygen species / William Nauseef

Cell adhesion molecules / Lucy V. Norling [and others]

Immunopharmacology

Mediators and mechanisms of inflammatory pain / Tony L. Yaksh.

Non-steroidal anti-inflammatory drugs / Roderick Flower

Cytokines and chemokines in inflammation cancer / Thorsten Hagemann and Toby Lawrence

Inflammatory Diseases/Histology

Lung / Bruce D. Levy

Neural inflammation, Alzheimers disease and stroke / Andrew P. Lieberman and Constance D'Amato

Rheumatoid arthritis/SLE / Karim Raza and Caroline Gordon

Gastrointestinal inflammation and ulceration: mediators of induction and resolution / Linda Vong, Paul L. Beck, and John Wallace

Inflammatory skin diseases / Gayathri K. Perera and Frank Nestle

Kidney glomerulonephritis and renal ischemia / Jeremy Duffield and Joel M. Henderson

Inflammation in cardiovascular diseases / Kenneth K. Wu

Animal Models of Inflammation

Models of acute inflammation: air-pouch, peritonitis and ischemia-reperfusion / Andre L.F. Sampaio, Neil Dufton, and Mauro Perretti

Experimental models of glomerulonephritis / Aidan Ryan, Denise M. Sadlier, and Catherine Godson

Glomerulonephritis and ischemia reperfusion injury / Jagdeep Obhrai and Jeremy S. Duffield

Asthma / Bruce D. Levy

Animal models of rheumatoid arthritis / H.B. Patel [and others]

Ocular inflammation models / Karsten Gronert

Atherosclerosis in experimental animal models / Aksam Merched and Lawrence Chan

Oral inflammation and periodontitis / Alpdogan Kantarci, Hatice Hasturk, and Thomas E. Van Dyke

Pathogens and inflammation / Fabiana S. Machado and Julio Aliberti.

Notes:

Title from publisher's bibliographic system (viewed on 05 Oct 2015).

Includes bibliographical references and index.

ISBN:

1-139-93147-4

1-107-21162-X

1-139-19573-5

1-282-63141-1

9786612631412

0-511-72878-6

0-511-72783-6

0-511-72644-9

0-511-72973-1

0-511-72502-7

OCLC:

761647059