Microfluidics for biotechnology / Jean Berthier, Pascal Silberzan.

Format:

Book

Author/Creator:

Berthier, Jean, 1952-

Contributor:

Silberzan, Pascal.

Series:

Artech House integrated microsystems series.

Integrated microsystems series

Language:

English

Subjects (All):

Biotechnology.

Microfluidics.

Physical Description:

1 online resource (502 p.)

Edition:

2nd ed.

Place of Publication:

Boston : Artech House, c2010.

Language Note:

English

System Details:

data file

Summary:

The application of microfluidics to biotechnology is an exciting new area that has already begun to revolutionize how researchers study and manipulate macromolecules like DNA, proteins and cells in vitro and within living organisms. Now in a newly revised and expanded second edition, the Artech House bestseller, Microfluidics for Biotechnology brings you to the cutting edge of this burgeoning field. Among the numerous updates, the second edition features three entirely new chapters on: non-dimensional numbers in microfluidics; interface, capillarity and microdrops; and digital, two-phase and droplet microfluidics. Presenting an enlightening balance of numerical approaches, theory, and experimental examples, this book provides a detailed look at the mechanical behavior of the different types of micro/nano particles and macromolecules that are used in biotechnology. You gain a solid understanding of microfluidics theory and the mechanics of microflows and microdrops. The book examines the diffusion of species and nanoparticles, including continuous flow and discrete Monte-Carlo methods. This unique volume describes the transport and dispersion of biochemical species and particles. You learn how to model biochemical reactions, including DNA hybridization and enzymatic reactions. Moreover, the book helps you master the theory, applications, and modeling of magnetic beads behavior and provides an overview of self-assembly and magnetic composite. Other key topics include the electric manipulation of micro/nanoparticles and macromolecules and the experimental aspects of biological macromolecule manipulation. Publisher abstract.

Contents:

Microfluidics for Biotechnology Second Edition; Contents; Preface; Acknowledgements; Chapter 1 Dimensionless Numbers in Microfluidics; 1.1 Introduction; 1.2 Microfluidic Scales; 1.3 Buckingham's Pi Theorem; 1.4 Scaling Numbers and Characteristic Scales; 1.4.1 Micro- to Nanoscales; 1.4.2 Hydrodynamic Characteristic Times; 1.4.3 Newtonian Fluids; 1.4.4 Non-Newtonian Fluids; 1.4.5 Droplets and Digital Microfluidics; 1.4.6 Multiphysics; 1.4.7 Specific Dimensionless Numbers and Composite Groups; References; Chapter 2 Microflows; 2.1 Introduction

2.1.1 On the Importance of Microfluidics in Biotechnology2.1.2 From Single Continuous Flow to Droplets; 2.2 Single-Phase Microflows; 2.2.1 Navier-Stokes (NS) Equations; 2.2.2 Non-Newtonian Rheology; 2.2.3 Laminarity of Microflows; 2.2.4 Stokes Equation; 2.2.5 Hagen-Poiseuille Flow; 2.2.6 Pressure Drop and Friction Factor; 2.2.7 Bernoulli's Approach; 2.2.8 Modeling: Lumped Parameters Model; 2.2.9 Microfluidic Networks: Worked Example 1-Microfluidic Flow Inside a Microneedle; 2.2.10 Microfluidic Networks: Worked Example 2-Plasma Extraction from Blood

2.2.11 Hydrodynamic Entrance Length: Establishment of the Flow2.2.12 Distributing a Uniform Flow into a Microchamber; 2.2.13 The Example of a Protein Reactor; 2.2.14 Recirculation Regions; 2.2.15 Inertial Effects at Medium Reynolds Numbers: Dean Flow; 2.2.16 Microflows in Flat Channels: Helle-Shaw Flows; 2.3 Conclusion; References; Chapter 3 Interfaces, Capillarity, and Microdrops; 3.1 Introduction; 3.2 Interfaces and Surface Tension; 3.2.1 The Notion of Interface; 3.2.2 Surface Tension; 3.3 Laplace Law and Applications; 3.3.1 Curvature Radius and Laplace's Law

3.3.2 Examples of the Application of Laplace's Law3.4 Partial or Total Wetting; 3.5 Contact Angle: Young's Law; 3.5.1 Young's Law; 3.5.2 Young's Law for Two Liquids and a Solid; 3.5.3 Generalization of Young's Law-Neumann's Construction; 3.6 Capillary Force and Force on a Triple Line; 3.6.1 Introduction; 3.6.2 Capillary Force Between Two Parallel Plates; 3.6.3 Capillary Rise in a Tube-Jurin's Law; 3.6.4 Capillary Rise Between Two Parallel Vertical Plates; 3.6.5 Capillary Pumping; 3.6.6 Force on a Triple Line; 3.6.7 Examples of Capillary Forces in Microsystems; 3.7 Pinning and Canthotaxis

3.7.1 Theory3.7.2 Pinning of an Interface Between Pillars; 3.7.3 Droplet Pinning on a Surface Defect; 3.7.4 Pinning of a Microdroplet-Quadruple Contact Line; 3.7.5 Pinning in Microwells; 3.8 Microdrops; 3.8.1 Shape of Microdrops; 3.8.2 Drops on Inhomogeneous Surfaces; 3.9 Conclusions; References; Chapter 4 Digital, Two-Phase, and Droplet Microfluidics; 4.1 Introduction; 4.2 Digital Microfluidics; 4.2.1 Introduction; 4.2.2 Theory of Electrowetting; 4.2.3 EWOD Microsystems; 4.2.4 Conclusion; 4.3 Multiphase Microflows; 4.3.1 Introduction; 4.3.2 Droplet and Plug Flow in Microchannels

Notes:

Description based upon print version of record.

Print version record.

Includes bibliographical references and index.

ISBN:

1-59693-444-1

OCLC:

796382985