Targeting protein kinases for cancer therapy / David J. Matthews, Mary E. Gerritsen.

Format:

Book

Author/Creator:

Matthews, David J. (David John), 1965-

Contributor:

Gerritsen, Mary E.

Language:

English

Subjects (All):

Protein kinases--Inhibitors--Therapeutic use.

Protein kinases.

Antineoplastic agents.

Physical Description:

1 online resource (798 p.)

Edition:

1st ed.

Place of Publication:

Hoboken, N.J. : John Wiley & Sons, c2010.

Language Note:

English

Summary:

An expert guide to targeting protein kinases in cancer therapy Research has shown that protein kinases can instigate the formation and spread of cancer when they transmit faulty signals inside cells. Because of this fact, pharmaceutical scientists have targeted kinases for intensive study, and have been working to develop medicinal roadblocks to sever their malignant means of communication. Complete with full-color presentations, Targeting Protein Kinases for Cancer Therapy defines the structural features of protein kinases and examines their cellular functions. Combining kin

Contents:

TARGETING PROTEIN KINASES FOR CANCER THERAPY; CONTENTS; Preface; Acknowledgments; 1 KINASES AND CANCER; 2 PROTEIN KINASE STRUCTURE, FUNCTION, AND REGULATION; 3 RECEPTOR TYROSINE KINASES; 4 NONRECEPTOR TYROSINE KINASES; 5 INTRACELLULAR SIGNAL TRANSDUCTION CASCADES; 6 CELL CYCLE CONTROL; 7 STRUCTURAL BIOCHEMISTRY OF KINASE INHIBITORS; 8 TYROSINE KINASE INHIBITORS; 9 ANGIOKINASE INHIBITORS; 10 INTRACELLULAR SIGNALING KINASE INHIBITORS; 11 CURRENT CHALLENGES AND FUTURE DIRECTIONS; References; List of Abbreviations; Index

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

ISBN:

9786612551284

9781118210772

1118210778

9781282551282

1282551280

9780470555293

0470555297

9780470555286

0470555289

OCLC:

587389347