Cell-based biosensors : principles and applications / Ping Wang, Qingjun Liu, editors.

Format:

Book

Contributor:

Liu, Qingjun.

Wang, Ping, 1959-

Series:

Artech House engineering in medicine & biology series.

Artech House series engineering in medicine & biology

Language:

English

Subjects (All):

Biosensors.

Cellular signal transduction.

Transducers.

Physical Description:

1 online resource (290 p.)

Edition:

1st ed.

Other Title:

Cell based biosensors

Place of Publication:

Norwood, MA : Artech House, c2010.

Language Note:

English

System Details:

data file

Summary:

In the 21st century, we are witnessing the integration of two dynamic disciplines - electronics and biology. As a result bioelectronics and biosensors have become of particular interest to engineers and researchers working in related biomedical areas. Written by recognized experts the field, this leading-edge resource is the first book to systematically introduce the concept, technology, and development of cell-based biosensors. Readers find details on the latest cell-based biosensor models and novel micro-structure biosensor techniques. Taking an interdisciplinary approach, this unique volume presents the latest innovative applications of cell-based biosensors in a variety of biomedical fields. The book also explores future trends of cell-based biosensors, including integrated chips, nanotechnology and microfluidics. Over 140 illustrations help clarify key topics throughout the book. Publisher abstract.

Contents:

Cell-Based Biosensors Principles and Applications; Contents; Foreword; Preface; Acknowledgments; Chapter 1 Introduction; 1.1 Definition of Cell-Based Biosensors; 1.2 Characteristics of Cell-Based Biosensors; 1.3 Types of Cell-Based Biosensors; 1.4 Summary; References; Chapter 2 Cell Culture on Chips; 2.1 Introduction; 2.2 Cell Immobilization Factors; 2.2.1 Physical Factors; 2.2.2 Chemical Factors; 2.2.3 Biological Factors; 2.3 Basic Surface Modification Rules; 2.3.1 Hydrophilicity Improving; 2.3.2 Roughness Changing; 2.3.3 Chemical Coating; 2.4 Typical Methods

2.4.1 Special Physical Structure 2.4.2 Microcontact Printing; 2.4.3 Fast Ink-Jet Printing; 2.4.4 Perforated Microelectrode; 2.4.5 Self-Assembled Monolayer; 2.4.6 Microfluidic Technology; 2.5 Summary; References; Chapter 3 Mechanisms of Cell-Based Biosensors; 3.1 Introduction; 3.2 Metabolic Measurements; 3.2.1 Cell Metabolism; 3.2.2 Extracellular pH Monitoring; 3.2.3 Other Extracellular Metabolite Sensing; 3.2.4 Secondary Transducers; 3.3 Action Potential Measurements; 3.3.1 Action Potential; 3.3.2 The Solid-Electrolyte Interface; 3.3.3 Cell-Electrode Interface Model

3.3.4 Cell-Silicon Interface Model 3.3.5 Secondary Transducers; 3.4 Impedance Measurements; 3.4.1 Membrane Impedance; 3.4.2 Impedance Model of Single Cells; 3.4.3 Impedance Model of Populations of Cells; 3.4.4 Secondary Transducers; 3.5 Noise Sources; 3.5.1 Electrode Noise; 3.5.2 Electromagnetic Interference; 3.5.3 Biological Noise; 3.6 Summary; References; Chapter 4 Microelectrode Array (MEA) as Cell-Based Biosensors; 4.1 Introduction; 4.2 Principle; 4.3 Fabrication and Design of MEA System; 4.3.1 Fabrication; 4.3.2 Different MEA Chips; 4.3.3 Measurement Setup

4.4 Theoretical Analysis of Signal Process in MEA Systems 4.4.1 Equivalent Circuit Model of Signal Process; 4.4.2 Impedance Properties Analysis of MEA; 4.4.3 Analysis of Extracellular Signal; 4.5 Application of MEA; 4.5.1 Dissociated Neural Network on MEA; 4.5.2 Slice on MEA; 4.5.3 Retina on MEA; 4.5.4 Pharmacological Application; 4.6 Development Trends; 4.6.1 Lab on a Chip; 4.6.2 Portable MEA System; 4.6.3 Other Developmental Trends; 4.7 Summary; References; Chapter 5 Field Effect Transistor (FET) as Cell-BasedBiosensors; 5.1 Introduction; 5.2 Principle; 5.3 Device and System

5.3.1 Fabrication of FET-Based Biosensor 5.3.2 FET Sensor System; 5.4 Theoretical Analysis; 5.4.1 Area-Contact Model; 5.4.2 Point-Contact Model; 5.5 Application; 5.5.1 Electrophysiological Recording of Neuronal Activity; 5.5.2 Two-Way Communication Between Silicon Chip and Neuron; 5.5.3 Neuronal Network Study; 5.5.4 Cell Microenvironment Monitoring; 5.6 Development Trends; 5.7 Summary; References; Chapter 6 Light Addressable Potentiometric Sensor (LAPS) as Cell-Based Biosensors; 6.1 Introduction; 6.2 Principle; 6.2.1 Fundamental; 6.2.2 Numerical Analysis; 6.3 Device and System; 6.3.1 Device

Notes:

Description based upon print version of record.

Print version record.

Includes bibliographical references and index.

ISBN:

1-59693-440-9

OCLC:

796382964