Handbook of cardiac stem cell therapy / edited by Ioannis Dimarakis ... [et al.].

Format:

Book

Contributor:

Dimarakis, Ioannis.

Language:

English

Subjects (All):

Heart--Diseases--Treatment.

Heart.

Stem cells--Transplantation.

Stem cells.

Physical Description:

1 online resource (306 p.)

Edition:

1st ed.

Place of Publication:

London : Imperial College Press, c2009.

Language Note:

English

Summary:

This book is an impressive compilation of contributions on the hot topic of cardiac stem cell therapy from leading groups all over the world. In the assembly of chapters, a structured approach is adopted; starting from the clinician's perspective, all developments in both the experimental and clinical research areas are covered. This journey will take the reader from the bench-top to the bedside, with all chapters written by leading authorities in their respective fields, including data still in press with medical journals.

Contents:

3. Embryonic Stem Cells and Their Therapeutic Potential Tomo Šari ́c, Shuhua Chen, Naidu Kamisseti, Marcel Halbach, Michael Xavier Doss, Johannes Winkler, Jürgen Hescheler and Agapios Sachinidis Embryonic Stem Cells; ES Cell-Derived Cardiomyocytes; Generation of cardiomyocytes from ES cells; Functional characteristics of ES cell-derived cardiomyocytes; Animal models of cardiomyocytes derived from ES cells; Other Animal Models for ES Cell-Based Therapeutics; Models for neural diseases; Models for therapy for type I diabetes mellitus; Animal models for liver and kidney regeneration

Cell replacement therapy for other organ systems Barriers to Successful Use of ES Cell-Based Therapies; Ethical concerns; Safety concerns and purity; Rejection of allogeneic cells; Conclusions; References; 4. Umbilical Cord Blood Cells for Cardiac Repair Elad Maor, Arnon Nagler and Jonathan Leor; Introduction; Myocardial Infarction and Heart Failure; Myocardial Regeneration and Cell-Based Therapy; Problems with the Available Cell Sources; The Rationale for Using UCB Progenitor Cells for Myocardial Repair; Data from Animal Models; How Do Cord Blood Cells Repair Ischemic Tissue?

Ex vivo Expansion Immunosuppression and Graft versus Host Disease; Summary; References; 5. Amniotic Stem Cells Paolo De Coppi, Anthony Atala and Saverio Sartore; Introduction; Amniocentesis; Differentiated Cells from Amniotic Fluid; Mesenchymal Stem Cells from Amniotic Fluid; Amniotic Fluid Stem Cells; Cell preparation and culture methods; Cell cloning; Telomerase activity; Differentiation potential induction of osteogenic phenotype; Induction of adipogenic lineage; Induction of myogenic phenotype; Induction of endothelial phenotype; Induction of hepatocytes phenotype

Induction of neurogenic phenotype Clonal and proliferative analyses; Conclusion; References; 6. Stem Cell Homing to Injury in Cellular Cardiomyoplasty Adil Al Kindi, Dominique Shum-Tim and Ray Chu-Jeng Chiu; Introduction; The Prelude: Insights from Bone Marrow Transplantation; Animal Studies; The Signaling Molecules; Summary and Conclusions; References; 7. A Molecular Imaging Perspective on Cardiac Repair with Stem Cells Kishore Bhakoo; Introduction; Radionuclide Imaging; Optical Imaging; Ultrasound; MRI Imaging; Intracellular MRI Contrast Agents; MRI Tracking of Stem Cells in the Heart

Multimodality

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

ISBN:

9786612440861

9781282440869

1282440861

9781848162570

184816257X

OCLC:

647850790