Translational multimodality optical imaging / Fred S. Azar, Xavier Intes, editors.

Format:

Book

Contributor:

Azar, Fred S.

Intes, Xavier.

Series:

Artech House bioinformatics & biomedical imaging series.

Artech House series bioinformatics & biomedical imaging

Language:

English

Subjects (All):

Diagnostic imaging--Digital techniques.

Diagnostic imaging.

Imaging systems in medicine.

Spectroscopic imaging.

Physical Description:

xxi, 386 p., [24] p. of plates : ill. (some col.) ; 27 cm.

Edition:

1st ed.

Place of Publication:

Boston : Artech House, c2008.

Language Note:

English

Summary:

Written by pioneers in the field, this first-of-its-kind resource on multimodal optical imaging provides you with a rigorous treatment of the various techniques together with the latest clinical advances in cancer detection and other important applications. You find full details on the principles, instrumentation, and methods of in vivo microscopy, optical coherence tomography, endoscopy, and diffuse optical techniques.

Contents:

Translational Multimodality Optical Imaging

Contents

Foreword

Preface

Translational Research

Optical Imaging

A Case Example of Translational Optical Imaging: The Network forTranslational Research in Optical Imaging

Aim and Scope of This Book

Acknowledgments

Ref erences

Chapter 1: Introduction to Clinical Optical Imaging

1.1 Introduction

1.2 Tissue Optics

1.2.1 Scattering

1.2.2 Raman Scattering

1.2.3 Absorption

1.2.4 Fluorescence

1.3 Light Propagation

1.3.1 Fundamentals

1.3.2 Forward Model

1.4 Multimodality Imaging

1.4.1 A Brief History of Clinical Multimodality Imaging

1.4.2 Multimodality Optical Imaging

1.5 Conclusions

References

Chapter 2: In Vivo Microscopy

2.1 Introduction

2.2 Confocal Microscopy

2.3 Endoscope-Compatible Systems

2.4 MKT Cellvizio-GI

2.5 Dual-Axes Confocal Microscope

2.6 Molecular Imaging

Chapter 3: Endoscopy

3.1 Introduction

3.2 Point-Probe Spectroscopy Techniques

3.2.1 Scattering Spectroscopy

3.2.2 Fluorescence Spectroscopy

3.2.3 Raman Spectroscopy

3.2.4 Multimodality Spectroscopy

3.3 Wide-Field Imaging

3.3.1 Fluorescence Imaging

3.3.2 Molecular Imaging

3.3.3 Chromoendoscopy

3.3.4 Narrowband Imaging

3.3.5 Multimodality Wide-Field Imaging

3.4 Cross-Sectional Imaging

3.4.1 Endoscopic Optical Coherence Tomography

3.4.2 Ultrahigh-Resolution OCT (UHROCT)

3.4.3 Three-Dimensional OCT

3.4.4 Multimodality Imaging with OCT

3.5 Summary

Chapter 4: Diffuse Optical Techniques: Instrumentation

4.1 Introduction: Deterministic "Diffuse" Detection of Probabilistic Photon Propagation

4.2 Methods of Differentiating the Origin of Diffuse Photons

4.2.1 The Source-Encoding Requirement in DOT.

4.2.2 Methods of Source Encoding and Detector Decoding for Diffuse Optical Tomography

4.3 Techniques of Decoupling the Absorption and Scattering Contributions to the Photon Remission

4.3.1 Time-Domain Detection

4.3.2 Frequency-Domain Detection

4.3.3 Continuous-Wave Detection

4.4 Principles of Determining the Heterogeneity of Optical Properties

4.4.1 Tomographic Image Reconstruction and Prior Utilization

4.4.2 Diffuse Optical Tomography Imaging in the Context of MultimodalityImaging

4.5 Novel Approaches in Instrumentation of Diffuse Optical Tomography: Source Spectral Encoding

4.5.1 Discrete Spectral Encoding by Use of Multiple Laser Diodes

4.5.2 Imaging Examples of Spectral-Encoding Rapid NIR Tomography

4.5.3 Spread Spectral Encoding by Use of Single Wideband Light Source

4.5.4 Light Sources for Spread Spectral Encoding

4.5.5 Characteristics of Spread Spectral Encoding

4.5.6 Hemodynamic Imaging by Spread-Spectral-Encoding NIR Tomography

4.6 Novel Approaches in Instrumentation of Diffuse Optical Tomography: Transrectal Applicator

4.6.1 Transrectal Applicator for Transverse DOT Imaging

4.6.2 Transrectal Applicator for Sagittal DOT Imaging

4.7 Potential Directions of Instrumentation for Diffuse Optical Measurements

4.8 Conclusions

Chapter 5: Multimodal Diffuse Optical Tomography:Theory

5.1 Introduction

5.2 Diffuse Optical Tomography

5.2.1 The Forward Problem and Linearization

5.2.2 Inverse Problem

5.3 Multimodality Reconstruction: Review of Previous Work

5.4 Multimodality Priors and Regularization

5.4.1 Structural Priors

5.4.2 Regularization Using Mutual Information

5.5 Conclusions

Chapter 6: Diffuse Optical Spectroscopy with Magnetic Resonance Imaging

6.1 Introduction

6.2 Anatomical Imaging.

6.3 Combining Hemodynamic Measures of MRI and Optical Imaging

6.4 MRI-Guided Optical Imaging Reconstruction Techniques

6.5 Other MR-Derived Contrast and Optical Imaging

6.6 Hardware Challenges to Merging Optical and MRI

6.7 Optical/MR Contrast Agents

6.8 Outlook for MR-Optical Imaging

Chapter 7: Software Platforms for Integration of Diffuse Optical Imaging and OtherModalities

7.1 Introduction

7.1.1 A Platform for Diffuse Optical Tomography

7.1.2 A Platform for Diffuse Optical Spectroscopy

7.2 Imaging Platform Technologies

7.2.1 Multimodal Imaging Workflow for DOT Applications

7.2.2 3D-DOT/3D-MRI Image-Registration Algorithm

7.2.3 Breast MRI Image Segmentation

7.2.4 Image-Based Guidance Workflow and System for DOS Applications

7.3 Computing the Accuracy of a Guidance and Tracking System

7.3.1 Global Accuracy of the System

7.3.2 Motion Tracking

7.4 Application to Nonconcurrent MRI and DOT Data of Human Subjects

7.5 Conclusion

Chapter 8: Diffuse Optical Spectroscopy in Breast Cancer: Coregistration with MRI and Predicting Response to Neoadjuvant Chemotherapy

8.1 Introduction

8.2 Coregistration with MRI

8.2.1 Materials and Methods

8.2.2 Results

8.2.3 Discussion

8.3 Monitoring and Predicting Response to Breast Cancer Neoadjuvant Chemotherapy

8.3.1 Materials and Methods

8.3.2 Results

8.3.3 Discussion

8.4 Summary and Conclusions

Chapter 9: Optical Imaging and X-Ray Imaging

9.1 Introduction

9.1.1 Current Clinical Approach to Breast Cancer Screening and Diagnosis

9.1.2 The Importance of Fusing Function and Structural Information

9.1.3 Recent Advances in DOT for Imaging Breast Cancer

9.2 Instrumentation and Methods.

9.2.1 Tomographic Optical Breast-Imaging System and Tomosynthesis

9.2.2 3D Forward Modeling and Nonlinear Image Reconstruction

9.2.3 Simultaneous Image Reconstruction with Calibration Coefficient Estimation

9.2.4 Utilizing Spectral Prior and Best Linear Unbiased Estimator

9.2.5 Utilizing Spatial Prior from Tomosynthesis Image

9.3 Clinical Trial of TOBI/DBT Imaging System

9.3.1 Image Reconstruction of Healthy Breasts

9.3.2 Imaging Breasts with Tumors or Benign Lesions

9.3.3 Region-of-Interest Analysis

9.4 Dynamic Imaging of Breast Under Mechanical Compression

9.4.1 Experiment Setup

9.4.2 Tissue Dynamic from Healthy Subjects

9.4.3 Contact Pressure Map Under Compression

9.5 Conclusions

Chapter 10: Diffuse Optical Imaging and PET Imaging

10.1 Introduction

10.2 Positron Emission Tomography (PET)

10.2.1 PET Fundamentals

10.2.2 PET Image Reconstruction

10.2.3 PET Instrumentation

10.3 Diffuse Optical Imaging (DOI)

10.3.1 DOI Instrumentation

10.3.2 DOI Image Reconstruction

10.4 Fluorescence Diffuse Optical Imaging (FDOI)

10.5 Clinical Observations

10.5.1 Whole-Body PET and DOI

10.5.2 Breast-Only PET and DOI

10.5.3 ICG Fluorescence

10.6 Summary

Chapter 11: Photodynamic Therapy

11.1 Introduction

11.2 Basics of PDT

11.3 Superficial Applications

11.4 PDT in Body Cavities

11.5 PDT for Solid Tumors

11.6 Delivery and Monitoring of PDT

11.7 The Future of PDT and Imaging

Chapter 12: Optical Phantoms for Multimodality Imaging

12.1 Introduction

12.2 Absorption and Scatter Phantom Composition

12.3 Typical Tissue Phantoms for Multimodal and Optical Imaging

12.3.1 Hydrogel-Based Phantoms

12.3.2 Polyester Resin and RTV Silicone Phantoms

12.3.3 Aqueous Suspension Phantoms.

12.4 Conclusions

Chapter 13: Intraoperative Near-Infrared Fluorescent Imaging Exogenous Fluorescence Contrast Agents

13.1 Introduction

13.2 Unmet Medical Needs Addressed by Intraoperative NIR Fluorescence Imaging

13.2.1 Improving Long-Term Efficacy of Primary Treatment

13.2.2 Reducing the Rate of Complications

13.3 Imaging Considerations

13.3.1 Contrast Media

13.3.2 Tissue Penetration Depth

13.3.3 Autofluorescence

13.3.4 Optical Design Considerations

13.3.5 Excitation

13.3.6 Collection Optics and Emission Filtering

13.3.7 Detectors

13.4 Future Outlook

Chapter 14: Clinical Studies in Optical Imaging: An Industry Perspective

14.1 Introduction

14.2 Breast Cancer

14.3 Optical Breast-Imaging Technology

14.4 Development Process

14.4.1 Product Definition

14.4.2 Clinical Indication

14.4.3 Target Markets

14.4.4 Regulatory Risk Classification

14.4.5 General Device Description

14.4.6 Design Control

14.5 Clinical Trials and Results

14.5.1 Clinical Plan

14.5.2 Pilot Studies

14.5.3 Tissue-Characterization Trials

14.6 Conclusions

Chapter 15: Regulation and Regulatory Science for Optical Imaging

15.1 Introduction

15.2 Fundamental Concepts in Medical Device Regulation

15.2.1 Premarket and Postmarket

15.2.2 Safety

15.2.3 Effectiveness

15.2.4 Risk Evaluation

15.2.5 Labeling

15.2.6 Standards

15.3 Medical Device Regulation Throughout the World

15.3.1 International Harmonization of Medical Device Regulation

15.4 FDA Background

15.4.1 FDA Mission

15.4.2 FDA History and Authorizing Legislation

15.4.3 Organizational Structure of the FDA

15.5 Overview of FDA Regulations

15.5.1 Classification

15.5.2 Early Premarket Interactions.

15.5.3 Premarket Submissions.

Notes:

Bibliographic Level Mode of Issuance: Monograph

Includes bibliographical references and index.

ISBN:

1-5231-1767-2

1-59693-308-9

OCLC:

871775260