Pathophysiology of nonalcoholic steatohepatitis / Metin Basaranoglu and Brent A. Neuschwander-Tetri.

Format:

Book

Author/Creator:

Basaranoglu, Metin.

Contributor:

Neuschwander-Tetri, Brent A.

Language:

English

Subjects (All):

Liver--Diseases.

Liver.

Fatty liver.

Physical Description:

1 online resource (122 p.)

Edition:

1st ed.

Place of Publication:

New York : Nova Biomedical Books, c2009.

Language Note:

English

Summary:

Rapid advances on molecular studies, manipulation of the mouse genome, the development of a number of animal models, and using these in studies of nonalcoholic fatty liver disease (NAFLD) have provided important insights into the pathogenesis of this relatively common disorder.

Contents:

""PATHOPHYSIOLOGY OFNONALCOHOLICSTEATOHEPATITIS""; ""NOTICE TO THE READER""; ""CONTENTS""; ""PREFACE""; ""ABBREVIATIONS""; ""PATHOPHYSIOLOGY OF EXCESSIVE FATACCUMULATION IN THE LIVER IN THEABSENCE OF ALCOHOL ABUSE: NAFLD""; ""OBESITY, INSULIN RESISTANCE ANDHYPERINSULINEMIA AS RISK FACTORS FOR NAFLD""; ""SOURCES OF LIVER FAT""; ""Dysregulated Peripheral Lipolysis""; ""Hepatic de Novo Lipogenesis (DNL)""; ""Uptake of Dietary Fat into the Liver""; ""FATES OF LIVER FAT""; ""Very-low-density Lipoprotein (VLDL) Synthesis and Secretion""; ""Mitochondrial β-Oxidation""

""Peroxisomal Fatty Acid β-Oxidation""""Cytochrome P450 Fatty Acid Ï? (Omega)-Oxidation""; ""Local and Generalized Inflammation in NAFLD""; ""NASH: THE PATHOGENESIS OFHEPATOCELLULAR INJURY IN NAFLD""; ""ROLE OF ANIMAL MODELS IN UNDERSTANDING THEPATHOGENESIS OF NASH""; ""The ob/ob Mouse""; ""The Methionine and Choline Deficient (MCD) Diet""; ""Other Dietary Models""; ""Transition from Simple Steatosis and NASH to NASH-AssociatedHCC: A new Murine NASH-Associated Hepatic Neoplasia Mo""; ""OXIDATIVE STRESS AND THE PATHOGENESIS OFNASH""; ""Mitochondria as a Source of Oxidant Stress""

""P450 as a Source of Oxidant Stress""""Iron, Oxidant Stress and NASH""; ""MITOCHONDRIAL DYSFUNCTION AND ATPDEPLETION""; ""FREE FATTY ACID TOXICITY""; ""ENDOGENOUS TOXINS:ENDOTOXIN AND GUT-DERIVED ETHANOL""; ""ADIPOCYTOKINES""; ""Leptin""; ""Adiponectin""; ""TNF-α""; ""IL-6""; ""Resistin""; ""Regulation of Hepatic Immunity and Increased Sensitivity toHepatocellular Injury""; ""HEPATOCYTE APOPTOSIS IN NAFLD""; ""HEPATIC FIBROGENESIS IN NASH""; ""ROLE OF STELLATE CELLS AND CYTOKINES INHEPATIC FIBROGENESIS""; ""HEPATOCELLULAR CARCI""; ""PATHOPHYSIOLOGY OF THEPATHOLOGICAL FEATURES OF NASH""

""MICROVESICULAR AND MACROVESICULAR STEATOSIS""""INFLAMMATION""; ""GLYCOGEN NUCLEI""; ""LIPOGRANULOMAS""; ""HEPATOCELLULAR BALLOONI""; ""HEPATOCELLULAR BALLOONING""; ""MALLORY BODIES AND STRESS PROTEINS""; ""GENETIC SUSCEPTIBILITY TO NASH AND THE BASISOF NASH-PATHOPHYSIOLOGY""; ""NASH Prevalence in Different Racial and Ethnic Groups""; ""NAFLD and Genes Associated with Lipid and Glucose Metabolism,Oxidant and Anti-Oxidant Systems, and ProinflammatoryCytokines""; ""SUMMARY""; ""REFERENCES""; ""INDEX""

Notes:

Description based upon print version of record.

Includes bibliographical references (p. [60]-97) and index.

ISBN:

1-60741-390-6

OCLC:

923657898