Recombinant antibodies for immunotherapy / edited by Melvyn Little.

Format:

Book

Contributor:

Little, Melvyn, 1945- editor.

Language:

English

Subjects (All):

Monoclonal antibodies--Therapeutic use.

Monoclonal antibodies.

Physical Description:

1 online resource (xiv, 419 pages) : digital, PDF file(s).

Edition:

1st ed.

Place of Publication:

Cambridge : Cambridge University Press, 2009.

Language Note:

English

Summary:

Recombinant Antibodies for Immunotherapy provides a comprehensive overview of the field of monoclonal antibodies (mAbs), a market that has grown tremendously in recent years. Twenty-five articles by experienced and innovative authors cover the isolation of specific human mAbs, humanization, immunogenicity, technologies for improving efficacy, 'arming' mAbs, novel alternative Ab constructs, increasing half-lives, alternative concepts employing non-immunoglobulin scaffolds, novel therapeutic approaches, a market analysis of therapeutic mAbs, and future developments in the field. The concepts and technologies are illustrated by examples of recombinant antibodies being used in the clinic or in development. This book will appeal to both newcomers and experienced scientists in the field, biology and biotechnology students, research and development departments in the pharmaceutical industry, medical researchers, clinicians, and biotechnology investors.

Contents:

Humanization of recombinant antibodies / José W. Saldanha

Immunogenicity assessment of antibody therapeutics / Philippe Stas [and others]

In vitro screening for antibody immunogenicity / Frank J. Carr and Matthew B. Baker

Antibody libraries from naïve V gene sources / Gerald Beste and David Lowe

Antibodies from IgM libraries / Stefan Knackmuss and Vera Molkenthin

Generation and screening of synthetic human combinatorial antibody library HuCAL GOLD / Ingo M. Klagge

Therapeutic antibodies from XenoMouse transgenic mice / Aya Jakobovits

VelocImmune : immunoglobulin variable region humanized mice / Andrew Murphy

Mechanisms of tumour cell killing by therapeutic antibodies / Ross Stewart and Carl Webster

Optimization of Fc domains to enhance antibody therapeutics / Greg A. Lazar and Aaron K. Chamberlain

Glycoengineered therapeutic antibodies / Peter Brünker, Peter Sondermann, and Pablo Umaña

Monoclonal antibodies for the delivery of cytotoxic drugs / David J. King.

Immunotherapy with radio-immune conjugates / Christina A. Kousparou and Agamemnon A. Epenetos

Immunotherapeutic antibody fusion proteins / Nigel S. Courtenay-Luck and David Jones

Alternative antibody formats / Fabrice Le Gall and Melvyn Little

Single-domain antibodies / Serge Muyldermans, Gholamreza Hassanzadeh Ghassabeh, and Dirk Saerens

Engineering of non-CDR loops in immunoglobulin domains / Florian Rüker and Gordana Wozniak-Knopp

Alternative scaffolds : expanding the options of antibodies / Andreas Plückthun

Polymer fusions to increase antibody half-lives : PEGylation and other modifications / Sam P. Heywood and David P. Humphreys

Extending antibody half-lives with albumin / Jan Terje Andersen and Inger Sandlie

A stem cell-based platform for the discovery and development of antitumor therapeutic antibodies to novel targets / Jennie P. Mather [and others]

Antibody directed enzyme prodrug therapy (ADEPT) / Helen L. Lowe [and others]

Immune privilege and tolerance

therapeutic antibody approaches / Daron Forman [and others]

Antibody therapeutics : business achievements and business outlook / Christophe Bourrilly.

Notes:

Title from publisher's bibliographic system (viewed on 05 Oct 2015).

Includes bibliographical references and index.

ISBN:

0-511-69892-5

1-107-20085-7

1-282-30321-X

9786612303210

0-511-59597-2

0-511-59637-5

0-511-59347-3

0-511-59254-X

0-511-59677-4

0-511-59540-9

OCLC:

609843039