Structure, function, and modulation of neuronal voltage-gated ion channels / Valentin K. Gribkoff, Leonard K. Kaczmarek.

Format:

Book

Author/Creator:

Gribkoff, Valentin K.

Contributor:

Kaczmarek, Leonard K.

Language:

English

Subjects (All):

Drug development.

Ion channels--Effect of drugs on.

Ion channels.

Molecular pharmacology.

Physical Description:

1 online resource (504 p.)

Edition:

1st ed.

Place of Publication:

Hoboken, N.J. : Wiley, c2009.

Language Note:

English

Summary:

This book discusses voltage-gated ion channels and their importance in drug discovery and development. The book includes reviews of the channel genome, the physiological bases of targeting ion channels in disease, the unique technologies developed for ion channel drug discovery, and the increasingly important role of ion channel screening in cardiac risk assessment. It provides an important reference for research scientists and drug discovery companies.

Contents:

STRUCTURE, FUNCTION, AND MODULATION OF NEURONAL VOLTAGE-GATED ION CHANNELS; CONTENTS; Preface; Contributors; PART I NEURONAL VOLTAGE-GATED ION CHANNEL FUNCTIONS; 1 Neuronal L-Type Voltage-Gated Calcium Channels; 2 Voltage-Gated N-Type and T-Type Calcium Channels and Excitability Disorders; 3 Voltage-Gated Sodium Channels: Multiple Roles in the Pathophysiology of Pain; 4 The Role of Ion Channels in the Etiology and Development of Gliomas; 5 Shaker Family K(v)1 Voltage-Gated Potassium Channels in Mammalian Brain Neurons

6 Unique Mitochondrial Ion Channels: Roles in Synaptic Transmission and Programmed Cell Death7 Regulation of Neuronal Excitability by the Sodium-Activated Potassium Channels Slick (SLO2.1) and Slack (SLO2.2); PART II MODULATORY MECHANISMS AND INFLUENCES ON NEURONAL VOLTAGE-GATED ION CHANNEL FUNCTION; 8 Alternative Splicing of Neuronal Ca(v)2 Calcium Channels; 9 Effect of Hypoxia/Ischemia on Voltage-Dependent Channels; 10 In Vivo Roles of Ion Channel Regulatory Protein Complexes in Neuronal Physiology and Behavior

11 Regulation of Neuronal Ion Channels by G-Protein-Coupled Receptors in Sympathetic Neurons12 BK Channels: Regulation of Expression and Physiological Impact; 13 Structural Basis for Auxiliary KChIP Modulation of K(v)4 Channels; PART III DRUG DISCOVERY TARGETS AND TECHNOLOGY; 14 Sodium Channel Blockers for the Treatment of Chronic Pain; 15 Neuronal K(v)7 Potassium Channels as Emerging Targets for the Treatment of Pain; 16 Small-Molecule Modulators of Large-Conductance, Calcium-Activated (BK) Channels; 17 High-Throughput Screening Technologies in Ion Channel Drug Discovery; Index

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

Description based on metadata supplied by the publisher and other sources.

ISBN:

9786612267796

9781282267794

1282267795

9780470429907

0470429909

9780470429891

0470429895

OCLC:

317473719