Gene transfer and the ethics of first-in-human research : lost in translation / Jonathan Kimmelman.

Format:

Book

Author/Creator:

Kimmelman, Jonathan, author.

Language:

English

Subjects (All):

Gene therapy--Moral and ethical aspects.

Gene therapy.

Clinical trials--Moral and ethical aspects.

Clinical trials.

Physical Description:

1 online resource (xi, 205 pages) : digital, PDF file(s).

Edition:

1st ed.

Other Title:

Gene Transfer & the Ethics of First-in-Human Research

Place of Publication:

Cambridge : Cambridge University Press, 2010.

Summary:

Human gene transfer is widely regarded as one of the most promising technologies for the treatment of a variety of disorders, but it presents practitioners with a variety of difficult ethical questions. Gene Transfer and the Ethics of First-in-Human Research examines the ethical and policy dimensions of testing interventions in human beings for the first time. The book discusses the difficult ethical challenges that arise from attempting to translate laboratory discoveries into clinical applications. These range from which available techniques to use, when to initiate human testing, questions of consent, expectation in public arenas, how to define acceptable risk, and the inclusion of vulnerable or disadvantaged subjects in early phase trials. This book is relevant to ethicists, legal practitioners, policy makers, geneticists and clinicians involved in clinical trials of new medical interventions.

Contents:

Introduction: gene transfer lost in translation

What is gene transfer?

Safety, values, and legitimacy: the protean nature of risk in translational trials

Taming uncertainty: risk and gene-transfer clinical research

Succor or suckers? Benefit, risk, and the therapeutic misconception

Looking backward: a model value for translational trials

The chasm: the ethics of initiating first-in-human clinical trials

Tropic of cancers: gene transfer in resource-poor settings

Great expectations and hard times: expectation management in gene transfer

Something in the sight adjusts itself: conclusions.

Notes:

Title from publisher's bibliographic system (viewed on 05 Oct 2015).

Includes bibliographical references and index.

ISBN:

0-511-84765-3

1-107-20737-1

0-511-64185-0

0-511-63941-4

0-511-64049-8

0-511-63834-5

0-511-64236-9

OCLC:

593222021