Hormones, cognition and dementia : state of the art and emergent therapeutic strategies / edited by Eef Hogervorst [and others].

Format:

Book

Contributor:

Hogervorst, Eef, editor.

Language:

English

Subjects (All):

Dementia--Prevention.

Dementia.

Estrogen--Therapeutic use.

Estrogen.

Physical Description:

1 online resource (xii, 280 pages) : digital, PDF file(s).

Edition:

1st ed.

Other Title:

Hormones, Cognition & Dementia

Place of Publication:

Cambridge : Cambridge University Press, 2009.

Language Note:

English

Summary:

A decade ago, oestrogen-containing hormone therapy was viewed as a promising strategy for the prevention and treatment of dementia and age-related cognitive decline. However, treatment trials in women with Alzheimer's disease showed that oestrogens did not reverse cognitive impairment, and clinical trials in healthy older women indicated that oestrogens did not prevent cognitive decline. The Women's Health Initiative Memory Study trial even suggested an increased risk of dementia with treatment late in life. What happened? How are we to understand these findings? What are the implications for middle-aged and older women? What about testosterone, and what about men? And where do we go from here? This book brings together world-renowned experts in basic and clinical research on sex steroids, aging, and cognition to integrate existing findings with emerging new data, and offer challenging hypotheses on these key issues.

Contents:

Estrogens and cognition: perspectives and opportunities in the wake of Women's Health Initiative Memory Study

Women's Health Initiative Memory Study (WHIMS) program: emerging findings

Identifying risk factors for cognitive change in the Women's Health Initiative: a neural networks approach

Estrogen therapy: relationship to longevity and prevalent dementia in the oldest-old: the Leisure World Cohort Study and the 90+ Study

Critical window hypothesis: hormone exposures and cognitive outcomes after menopause

Animal studies that support estrogen effects on cognitive performance and the cholinergic basis of the critical period hypothesis

Healthy cell bias of estrogen action through regulating glucose metabolism and mitochondrial function: implications for prevention of Alzheimer's disease

Varieties of estrogenic therapy

Alternative estrogenic treatment regimens and the Kronos Early Estrogen Prevention Study: Cognitive and Affective substudy (KEEPS-CA)

Use of transdermal 17-estradiol in the treatment of Alzheimer's disease

Alternative modes of treatment: pulsatile estradiol treatment

In search of estrogen alternatives for the brain

Potential modulators and modifiers of estrogenic effects

Progesterone regulation of neuroprotective estrogen actions

Clinical data of estrogen's effects in the central nervous system: estrogen and mood

Different forms of soy processing may determine the positive or negative impact on cognitive function of Indonesian elderly

Hypothalamus-pituitary-adrenal axis activity in aging women: its impact on the brain and the potential influence of estradiol

Possible genetic factors related to hormone treatment effects

Possible genetic polymorphisms related to sex steroid metabolism and dementia in women

Genetics related to sex steroids: implications for Alzheimer's disease

Apolipoprotein E, hormone therapy, and neuroprotection

Testosterone, gonadotropins, and genetic polymorphisms in men with Alzheimer's disease

Testosterone, estradiol and men, and sex hormone binding globulin

Androgens and cognitive functioning in women

Role of estradiol in testosterone treatment

Endogenous testosterone levels and cognitive aging in men

Clinical trials and neuroimaging studies of testosterone in men: insights into effects on verbal memory

Testosterone therapy and Alzheimer's disease: potential for treatment and prevention in women

Endogenous estradiol and dementia in elderly men: the roles of vascular risk, sex hormone binding globulin, and aromatase activity

Testosterone regulates Alzheimer's disease pathogenesis

Gonadotropin effects

Involvement of gonadotropins in cognitive function: implications for Alzheimer's disease

Role of gonadotropins and testosterone in the regulation of beta-amyloid metabolism.

Notes:

Title from publisher's bibliographic system (viewed on 05 Oct 2015).

Includes bibliographical references and index.

ISBN:

1-107-21241-3

0-511-69990-5

1-282-33693-2

9786612336935

0-511-63481-1

0-511-63526-5

0-511-63315-7

0-511-63194-4

0-511-63570-2

0-511-63436-6

OCLC:

609845539