Inhibin, activin, and follistatin in human reproductive physiology / editors, Shanthi Muttukrishna, William Ledger.

Format:

Book

Contributor:

Muttukrishna, Shanthi.

Ledger, William L.

Language:

English

Subjects (All):

Inhibin.

Glycoproteins.

Pregnancy--Physiological aspects.

Pregnancy.

Reproduction--Physiological aspects.

Reproduction.

Physical Description:

1 online resource (341 p.)

Edition:

1st ed.

Place of Publication:

London : Imperial College Press ; River Edge, NJ : Distributed by World Scientific Pub., 2001.

Language Note:

English

Summary:

An understanding of the participation of inhibin and activin in the regulation of the ovary and testis has provided illuminating insights into the physiology and pathology of human gonadal function. Rapid progress has been made in both reproductive physiology and possible applications in clinical practice. In addition, the discovery that both inhibin and activin are placental hormones with altered secretion in disease states, such as pre-eclampsia, has proven to be one of the most exciting aspects of work in this area of human biology. This book comprehensively reviews the current state of k

Contents:

CONTENTS ; FOREWORD ; CHAPTER 1 INTRODUCTION ; 1.1 Historical Background ; 1.2 Characterisation of Inhibin ; 1.3 Activin ; 1.4 Follistatin ; 1.5 Biological Functions ; References ; CHAPTER 2 DEVELOPMENT OF IMMUNOASSAYS FOR INHIBIN ACTIVIN AND FOLLISTATIN

2.1 Structures of Inhibin Activin and Follistatin 2.2 Implications of Molecular Structure for Immunoassay Development ; 2.3 Previous Assays ; 2.4 Preparation of Monoclonal Antibodies to Inhibin ; 2.5 The Oxford Brookes ELISAs ; 2.6 Assay Validation ; 2.7 Standardisation

2.8 Further Assays Needed in This Field 2.9 Conclusion ; References ; CHAPTER 3 ENDOCRINE AUTOCRINE AND PARACRINE ACTIONS OF INHIBIN ACTIVIN AND FOLLISTATIN ON FOLLICLE-STIMULATING HORMONE ; 3.1 Introduction ; 3.2 Control of FSH

3.3 Role of Inhibin Activin and Follistatin in the Control of FSH 3.4 Control of Pituitary Activin Bioavailability ; 3.5 Requirements for Establishing a Local Autocrine/Paracrine Role for the FSH Regulatory Proteins ; 3.6 Key Points and Future Direction ; References

CHAPTER 4 REGULATION OF PRODUCTION AND INTRAOVARIAN ROLES OF INHIBIN ACTIVIN AND FOLLISTATIN 4.1 Introduction ; 4.2 Expression of Inhibin Activin and Follistatin and their Receptors in the Primate Ovary ; 4.3 Factors Regulating Granulosa Cell Production of Inhibin Activin and Follistatin

4.4 Intrafollicular Actions of Inhibin Activin and Follistatin

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

ISBN:

9786611866013

9781281866011

1281866016

9781848161474

1848161476

OCLC:

815741829